Show simple item record

Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors

dc.contributor.authorKusuma, Bhaskar Reddy
dc.contributor.authorDuerfeldt, Adam S.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-05-04T18:39:43Z
dc.date.available2017-05-04T18:39:43Z
dc.date.issued2011-12-01
dc.identifier.citationKusuma, B. R., Duerfeldt, A. S., & Blagg, B. S. J. (2011). Synthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters, 21(23), 7170–7174. http://doi.org/10.1016/j.bmcl.2011.09.073en_US
dc.identifier.urihttp://hdl.handle.net/1808/23893
dc.description.abstractNovobiocin analogs lacking labile glycosidic ether have been designed, synthesized and evaluated for Hsp90 inhibitory activity. Replacement of the synthetically complex noviose sugar with simple aromatic side chains produced analogs that maintain moderate cytotoxic activity against MCF7 and SkBR3 breast cancer cell-lines. Rationale for the preparation of des-noviose novobiocin analogs in addition to their synthesis and biological evaluation are presented herein.en_US
dc.publisherElsevieren_US
dc.rightsThis article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us/en_US
dc.titleSynthesis and biological evaluation of arylated novobiocin analogs as Hsp90 inhibitorsen_US
dc.typeArticleen_US
kusw.kuauthorKusuma, Bhaskar Reddy
kusw.kuauthorDuerfeldt, Adam S.
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1016/j.bmcl.2011.09.073en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-3130-9890
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3242434en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail
Name:
Kusuma_Elsevier_2011.pdf
Size:
733.7Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record

This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.
Except where otherwise noted, this item's license is described as: This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.