ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated. If you have any questions, please contact Marianne Reed at mreed@ku.edu .

Show simple item record

Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors

dc.contributor.authorJadhav, Vinod D.
dc.contributor.authorDuerfeldt, Adam S.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-05-03T20:42:20Z
dc.date.available2017-05-03T20:42:20Z
dc.date.issued2009-12-15
dc.identifier.citationJadhav, V. D., Duerfeldt, A. S., & Blagg, B. S. J. (2009). Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters, 19(24), 6845–6850. http://doi.org/10.1016/j.bmcl.2009.10.091en_US
dc.identifier.urihttp://hdl.handle.net/1808/23882
dc.description.abstractBicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These analogues induce concentration-dependent degradation of Hsp90-dependent client proteins with the six-membered bicyclic analogues manifesting increased activity versus the five-membered counterparts.en_US
dc.publisherElsevieren_US
dc.rightsThis article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subjectHsp90en_US
dc.subjectGeldanamycinen_US
dc.subjectRadicicolen_US
dc.subjectAnti-canceren_US
dc.titleDesign, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitorsen_US
dc.typeArticleen_US
kusw.kuauthorJadhav, Vinod D.
kusw.kuauthorDuerfeldt, Adam S.
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1016/j.bmcl.2009.10.091en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-3130-9890
dc.identifier.orcidhttps://orcid.org/0000-0002-2918-6254
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2784232en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail
Name:
Jadhav_Elsevier_2009.pdf
Size:
981.8Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record

This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.
Except where otherwise noted, this item's license is described as: This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.