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Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors

dc.contributor.authorJadhav, Vinod D.
dc.contributor.authorDuerfeldt, Adam S.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-05-03T20:42:20Z
dc.date.available2017-05-03T20:42:20Z
dc.date.issued2009-12-15
dc.identifier.citationJadhav, V. D., Duerfeldt, A. S., & Blagg, B. S. J. (2009). Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors. Bioorganic & Medicinal Chemistry Letters, 19(24), 6845–6850. http://doi.org/10.1016/j.bmcl.2009.10.091en_US
dc.identifier.urihttp://hdl.handle.net/1808/23882
dc.description.abstractBicyclic radester analogues have been synthesized and evaluated for Hsp90 inhibitory activity. These analogues induce concentration-dependent degradation of Hsp90-dependent client proteins with the six-membered bicyclic analogues manifesting increased activity versus the five-membered counterparts.en_US
dc.publisherElsevieren_US
dc.rightsThis article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subjectHsp90en_US
dc.subjectGeldanamycinen_US
dc.subjectRadicicolen_US
dc.subjectAnti-canceren_US
dc.titleDesign, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitorsen_US
dc.typeArticleen_US
kusw.kuauthorJadhav, Vinod D.
kusw.kuauthorDuerfeldt, Adam S.
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1016/j.bmcl.2009.10.091en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-3130-9890
dc.identifier.orcidhttps://orcid.org/0000-0002-2918-6254
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2784232en_US
dc.rights.accessrightsopenAccess


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This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.
Except where otherwise noted, this item's license is described as: This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.