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Click Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analogues
| dc.contributor.author | Peterson, Laura B. | |
| dc.contributor.author | Blagg, Brian S. J. | |
| dc.date.accessioned | 2017-05-03T19:51:15Z | |
| dc.date.available | 2017-05-03T19:51:15Z | |
| dc.date.issued | 2010-07-01 | |
| dc.identifier.citation | Peterson, L. B., & Blagg, B. S. J. (2010). Click Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analogues. Bioorganic & Medicinal Chemistry Letters, 20(13), 3957–3960. http://doi.org/10.1016/j.bmcl.2010.04.140 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23880 | |
| dc.description.abstract | A series of triazole-containing novobiocin analogues has been designed, synthesized and their inhibitory activity determined. These compounds contain a triazole ring in lieu of the amide moiety present in the natural product. The anti-proliferative effects of these compounds were evaluated against two breast cancer cell lines (SKBr-3 and MCF-7), and manifested activities similar to their amide-containing counterparts. In addition, Hsp90-dependent client protein degradation was observed via western blot analysis, further supporting a common mode of Hsp90 inhibition for both structural classes. | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License. | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/ | en_US |
| dc.subject | Hsp90 | en_US |
| dc.subject | Novobiocin | en_US |
| dc.subject | Antiproliferation | en_US |
| dc.subject | Triazole | en_US |
| dc.title | Click Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analogues | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Blagg, Brian S. J. | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1016/j.bmcl.2010.04.140 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC2924929 | en_US |
| dc.rights.accessrights | openAccess |
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