Show simple item record

Click Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analogues

dc.contributor.authorPeterson, Laura B.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-05-03T19:51:15Z
dc.date.available2017-05-03T19:51:15Z
dc.date.issued2010-07-01
dc.identifier.citationPeterson, L. B., & Blagg, B. S. J. (2010). Click Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analogues. Bioorganic & Medicinal Chemistry Letters, 20(13), 3957–3960. http://doi.org/10.1016/j.bmcl.2010.04.140en_US
dc.identifier.urihttp://hdl.handle.net/1808/23880
dc.description.abstractA series of triazole-containing novobiocin analogues has been designed, synthesized and their inhibitory activity determined. These compounds contain a triazole ring in lieu of the amide moiety present in the natural product. The anti-proliferative effects of these compounds were evaluated against two breast cancer cell lines (SKBr-3 and MCF-7), and manifested activities similar to their amide-containing counterparts. In addition, Hsp90-dependent client protein degradation was observed via western blot analysis, further supporting a common mode of Hsp90 inhibition for both structural classes.en_US
dc.publisherElsevieren_US
dc.rightsThis article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subjectHsp90en_US
dc.subjectNovobiocinen_US
dc.subjectAntiproliferationen_US
dc.subjectTriazoleen_US
dc.titleClick Chemistry to Probe Hsp90: Synthesis and Evaluation of a Series of Triazole Containing Novobiocin Analoguesen_US
dc.typeArticleen_US
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1016/j.bmcl.2010.04.140en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2924929en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail
Name:
Peterson_Elsevier_2010.pdf
Size:
935.9Kb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record

This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.
Except where otherwise noted, this item's license is described as: This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License.