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Single injection of novel kappa opioid receptor agonist salvinorin A attenuates expression of cocaine induced behavioral sensitization in rats
dc.contributor.author | Morani, Aashish S. | |
dc.contributor.author | Schenk, Susan | |
dc.contributor.author | Prisinzano, Thomas E. | |
dc.contributor.author | Kivell, Bronwyn | |
dc.date.accessioned | 2017-04-12T19:51:02Z | |
dc.date.available | 2017-04-12T19:51:02Z | |
dc.date.issued | 2012-04 | |
dc.identifier.citation | Morani, A. S., Schenk, S., Prisinzano, T. E., & Kivell, B. (2012). Single injection of novel kappa opioid receptor agonist salvinorin A attenuates expression of cocaine induced behavioral sensitization in rats. Behavioural Pharmacology, 23(2), 162–170. http://doi.org/10.1097/FBP.0b013e3283512c1e | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23645 | |
dc.description.abstract | Kappa opioid receptor (KOPr) activation antagonizes many cocaine-related behaviors but adverse side effects such as sedation, dysphoria and depression limit their therapeutic use. Recently, salvinorin A (Sal A), a naturally occurring KOPr agonist, has been shown to attenuate cocaineinduced drug-seeking in a model of relapse in rats. The present study evaluated the effects of acute Sal A exposure on cocaine-induced hyperactivity and cocaine sensitization in rats. Acute treatment with the dose of Sal A that decreased drug-seeking in a previous study (0.3 mg/kg), significantly attenuated the expression of cocaine sensitization. This dose of Sal A failed to affect spontaneous locomotion or to produce a conditioned taste aversion to a novel-tasting saccharin solution. However, Sal A decreased climbing and swimming time and increased time spent immobile in the forced swim test. These findings indicate that Sal A, just like traditional KOPr agonists, attenuates cocaine-induced behavioral sensitization but does not produce the adverse effect of conditioned aversion, suggesting improved potential compliance. However, pro-depressive effects were also produced and these effects may limit the therapeutic potential. | en_US |
dc.publisher | Lippincott, Williams & Wilkins | en_US |
dc.rights | © 2012 Lippincott Williams & Wilkins, Inc. | en_US |
dc.subject | Salvinorin A | en_US |
dc.subject | Kappa opioid agonist | en_US |
dc.subject | Behavioural sensitization | en_US |
dc.subject | Conditioned taste aversion | en_US |
dc.subject | Forced swim test | en_US |
dc.subject | Depression | en_US |
dc.subject | Rat | en_US |
dc.title | Single injection of novel kappa opioid receptor agonist salvinorin A attenuates expression of cocaine induced behavioral sensitization in rats | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Prisinzano, Thomas E. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1097/FBP.0b013e3283512c1e | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |