ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Discovery of Dermorphin-Based Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors+
| dc.contributor.author | Sinha, Bhaswati | |
| dc.contributor.author | Cao, Zhengyu | |
| dc.contributor.author | Murray, Thomas F. | |
| dc.contributor.author | Aldrich, Jane V. | |
| dc.date.accessioned | 2017-04-06T16:45:34Z | |
| dc.date.available | 2017-04-06T16:45:34Z | |
| dc.date.issued | 2009-12-10 | |
| dc.identifier.citation | Sinha, B., Cao, Z., Murray, T. F., & Aldrich, J. V. (2009). Discovery of Dermorphin-Based Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors. Journal of Medicinal Chemistry, 52(23), 7372–7375. http://doi.org/10.1021/jm9007592 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/23589 | |
| dc.description.abstract | A series of potent electrophilic affinity labels (IC50 = 0.1-5 nM) containing either a bromoacetamide or isothiocyanate based on the mu opioid receptor (MOR) selective peptide dermorphin were prepared. All four analogs exhibited wash resistant inhibition of [3H]DAMGO binding at subnanomolar to nanomolar concentrations, suggesting that these analogs bind covalently to MOR. To our knowledge these peptides are the highest affinity peptide-based affinity labels for MOR reported to date. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm9007592. | en_US |
| dc.title | Discovery of Dermorphin-Based Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors+ | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Sinha, Bhaswati | |
| kusw.kuauthor | Aldrich, Jane V. | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1021/jm9007592 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess |
