Cannabinoid 2 Receptor- and Beta Arrestin 2-Dependent Upregulation of Serotonin 2A Receptors
dc.contributor.author | Franklin, Jade M. | |
dc.contributor.author | Vasiljevik, Tamara | |
dc.contributor.author | Prisinzano, Thomas E. | |
dc.contributor.author | Carrasco, Gonzalo A. | |
dc.date.accessioned | 2017-03-31T19:57:50Z | |
dc.date.available | 2017-03-31T19:57:50Z | |
dc.date.issued | 2012-07-28 | |
dc.identifier.citation | Franklin, J.m., T. Vasiljevik, T.e. Prisinzano, and G.a. Carrasco. "Cannabinoid 2 Receptor- and Beta Arrestin 2-dependent Upregulation of Serotonin 2A Receptors." European Neuropsychopharmacology 23.7 (2013): 760-67. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23556 | |
dc.description.abstract | Recent evidence suggests that cannabinoid receptor agonists may regulate serotonin 2A (5-HT2A) receptor neurotransmission in the brain, although no molecular mechanism has been identified. Here, we present experimental evidence that sustained treatment with a non-selective cannabinoid agonist (CP 55,940) or selective CB2 receptor agonists (JWH 133 or GP 1a) upregulate 5-HT2A receptors in a neuronal cell line. Furthermore, this cannabinoid receptor agonist-induced upregulation of 5-HT2A receptors was prevented in cells stably transfected with either CB2 or β-Arrestin 2 shRNA lentiviral particles. Additionally, inhibition of clathrin-mediated endocytosis also prevented the cannabinoid receptor-induced upregulation of 5-HT2A receptors. Our results indicate that cannabinoid agonists might upregulate 5-HT2A receptors by a mechanism that requires CB2 receptors and β-Arrestin 2 in cells that express both CB2 and 5-HT2A receptors. 5-HT2A receptors have been associated with several physiological functions and neuropsychiatric disorders such as stress response, anxiety & depression and schizophrenia. Therefore, these results might provide a molecular mechanism by which activation of cannabinoid receptors might be relevant to some cognitive and mood disorders in humans. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Cannabinoids | en_US |
dc.subject | CB2 receptors | en_US |
dc.subject | Serotonin | en_US |
dc.subject | Marijuana | en_US |
dc.subject | β-Arrestins | en_US |
dc.subject | Receptor internalization | en_US |
dc.subject | 5-HT2A receptor | en_US |
dc.title | Cannabinoid 2 Receptor- and Beta Arrestin 2-Dependent Upregulation of Serotonin 2A Receptors | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Prisinzano, Thomas E. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1016/j.euroneuro.2012.06.012 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.