The 2-Methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats
dc.contributor.author | Morani, Aashish S. | |
dc.contributor.author | Ewald, Amy | |
dc.contributor.author | Prevatt-Smith, Katherine M. | |
dc.contributor.author | Prisinzano, Thomas E. | |
dc.contributor.author | Kivell, Bronwyn | |
dc.date.accessioned | 2017-03-31T19:45:23Z | |
dc.date.available | 2017-03-31T19:45:23Z | |
dc.date.issued | 2013-11-04 | |
dc.identifier.citation | Morani, Aashish S., Amy Ewald, Katherine M. Prevatt-Smith, Thomas E. Prisinzano, and Bronwyn M. Kivell. "The 2-methoxy Methyl Analogue of Salvinorin A Attenuates Cocaine-induced Drug Seeking and Sucrose Reinforcements in Rats." European Journal of Pharmacology 720.1-3 (2013): 69-76. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23555 | |
dc.description.abstract | κ opioid receptor activation by traditional arylacetamide agonists and the novel neoclerodane diterpene κ opioid receptor agonist Salvinorin A (Sal A) results in attenuation of cocaine-seeking behavior in pre-clinical models of addiction. However, adverse effects such as sedation, depression and aversion limit their clinical utility. The Sal A analogue, 2-methoxymethyl salvinorin B (MOM Sal B) is a longer acting Sal A analogue with high affinity for κ opioid receptors. In this study, we tested MOM Sal B for its ability to modulate cocaine-seeking behavior in rats. MOM Sal B (0.3 mg/kg) successfully attenuated cocaine-seeking but also attenuated sucrose reinforcement. No change in activity was observed in either cocaine-induced hyperactivity or spontaneous open field activity tests but increased immobility and decreased swimming times in the forced swim test were observed. This study indicates that κ opioid receptor activation by more potent Sal A analogues modulates cocaine-seeking behavior non-selectively without causing sedation, suggesting an improved side effects profile. However, pro-depressive effects are seen, which may limit the therapeutic potential of this compound. Future studies with Sal A analogues having affinities at other opioid receptors are warranted as they have the potential to identify compounds having effective anti-addiction properties. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Cocaine | en_US |
dc.subject | Self-administration | en_US |
dc.subject | Salvinorin A | en_US |
dc.subject | Sucrose reinforcement | en_US |
dc.subject | Locomotion | en_US |
dc.subject | Forced swim test | en_US |
dc.title | The 2-Methoxy methyl analogue of salvinorin A attenuates cocaine-induced drug seeking and sucrose reinforcements in rats | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Prisinzano, Thomas E. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1016/j.ejphar.2013.10.050 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.