dc.contributor.author | Matts, Robert L. | |
dc.contributor.author | Dixit, Anshuman | |
dc.contributor.author | Peterson, Laura B. | |
dc.contributor.author | Sun, Liang | |
dc.contributor.author | Voruganti, Sudhakar | |
dc.contributor.author | Kalyanaraman, Palgunan | |
dc.contributor.author | Hartson, Steve D. | |
dc.contributor.author | Verkhivker, Gennady M. | |
dc.contributor.author | Blagg, Brian S. J. | |
dc.date.accessioned | 2017-03-30T17:49:33Z | |
dc.date.available | 2017-03-30T17:49:33Z | |
dc.date.issued | 2011-08-19 | |
dc.identifier.citation | Matts, R. L., Dixit, A., Peterson, L. B., Sun, L., Voruganti, S., Kalyanaraman, P., … Blagg, B. S. J. (2011). Elucidation of the Hsp90 C-terminal Inhibitor Binding Site. ACS Chemical Biology, 6(8), 800–807. http://doi.org/10.1021/cb200052x | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23521 | |
dc.description.abstract | The Hsp90 chaperone machine is required for the folding, activation and/or stabilization of more than 50 proteins directly related to malignant progression. Hsp90 contains small molecule binding sites at both its N- and C-terminal domains, however, limited structural and biochemical data regarding the C-terminal binding site is available. In this report, the small molecule binding site in
the Hsp90 C-terminal domain was revealed by protease fingerprinting and photoaffinity labeling utilizing LC-MS/MS. The identified site was characterized by generation of a homology model for hHsp90α using the SAXS open structure of HtpG and docking the bioactive conformation of NB into the generated model. The resulting model for the bioactive conformation of NB bound to Hsp90α is presented herein. | en_US |
dc.publisher | ACS Chem Biol. | en_US |
dc.rights | Copyright © 2011 American Chemical Society | en_US |
dc.title | Elucidation of the Hsp90 C-terminal Inhibitor Binding Site | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Dixit, Anshuman | |
kusw.kuauthor | Peterson, Laura B. | |
kusw.kuauthor | Blagg, Brian S. J. | |
kusw.kudepartment | Biochemistry and Molecular Biology | en_US |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1021/cb200052x | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |