ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone
dc.contributor.author | Holtz, Nathan A. | |
dc.contributor.author | Lozama, Anthony | |
dc.contributor.author | Prisinzano, Thomas E. | |
dc.contributor.author | Carroll, Marilyn E. | |
dc.date.accessioned | 2017-03-08T20:08:34Z | |
dc.date.available | 2017-03-08T20:08:34Z | |
dc.date.issued | 2013-01-01 | |
dc.identifier.citation | Holtz, Nathan A., Anthony Lozama, Thomas E. Prisinzano, and Marilyn E. Carroll. "Reinstatement of Methamphetamine Seeking in Male and Female Rats Treated with Modafinil and Allopregnanolone." Drug and Alcohol Dependence 120.1-3 (2012): 233-37. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23367 | |
dc.description.abstract | BackgroundSex differences in methamphetamine (METH) use (females>males) have been demonstrated in clinical and preclinical studies. This experiment investigated the effect of sex on the reinstatement of METH-seeking behavior in rats and to determine whether pharmacological interventions for METH-seeking behavior vary by sex. Treatment drugs were modafinil (MOD), an analeptic, and allopregnanolone (ALLO), a neuroactive steroid and progesterone metabolite.MethodMale and female rats were trained to self-administer i.v. infusions of METH (0.05mg/kg/infusion). Next, rats self-administered METH for a 10-day maintenance period. METH was then replaced with saline, and rats extinguished lever-pressing behavior over 18 days. A multi-component reinstatement procedure followed where priming injections of METH (1 mg/kg) were administered at the start of each daily session, preceded 30 min by MOD (128 mg/kg, i.p.), ALLO (15 mg/kg, s.c.), or vehicle treatment. MOD was also administered at the onset of the session to determine if it would induce the reinstatement of METH-seeking behavior.ResultsFemale rats had greater METH-induced reinstatement responding compared to male rats following control treatment injections. MOD (compared to the DMSO control) attenuated METH-seeking behavior in male and female rats; however, ALLO only reduced METH-primed responding in females. MOD alone did not induce the reinstatement of METH-seeking behavior.ConclusionsThese results support previous findings that females are more susceptible to stimulant abuse compared to males and ALLO effectively reduced METH-primed reinstatement in females. Further, they illustrate the utility of MOD as a potential agent for prevention of relapse to METH use in both males and females. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Allopregnanolone | en_US |
dc.subject | Methamphetamine | en_US |
dc.subject | Modafinil | en_US |
dc.subject | Rats | en_US |
dc.subject | Reinstatement | en_US |
dc.subject | Sex differences | en_US |
dc.title | Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Prisinzano, Thomas E. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1016/j.drugalcdep.2011.07.010 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.