Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone
dc.contributor.author | Holtz, Nathan A. | |
dc.contributor.author | Lozama, Anthony | |
dc.contributor.author | Prisinzano, Thomas E. | |
dc.contributor.author | Carroll, Marilyn E. | |
dc.date.accessioned | 2017-03-08T20:08:34Z | |
dc.date.available | 2017-03-08T20:08:34Z | |
dc.date.issued | 2013-01-01 | |
dc.identifier.citation | Holtz, Nathan A., Anthony Lozama, Thomas E. Prisinzano, and Marilyn E. Carroll. "Reinstatement of Methamphetamine Seeking in Male and Female Rats Treated with Modafinil and Allopregnanolone." Drug and Alcohol Dependence 120.1-3 (2012): 233-37. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23367 | |
dc.description.abstract | BackgroundSex differences in methamphetamine (METH) use (females>males) have been demonstrated in clinical and preclinical studies. This experiment investigated the effect of sex on the reinstatement of METH-seeking behavior in rats and to determine whether pharmacological interventions for METH-seeking behavior vary by sex. Treatment drugs were modafinil (MOD), an analeptic, and allopregnanolone (ALLO), a neuroactive steroid and progesterone metabolite.MethodMale and female rats were trained to self-administer i.v. infusions of METH (0.05mg/kg/infusion). Next, rats self-administered METH for a 10-day maintenance period. METH was then replaced with saline, and rats extinguished lever-pressing behavior over 18 days. A multi-component reinstatement procedure followed where priming injections of METH (1 mg/kg) were administered at the start of each daily session, preceded 30 min by MOD (128 mg/kg, i.p.), ALLO (15 mg/kg, s.c.), or vehicle treatment. MOD was also administered at the onset of the session to determine if it would induce the reinstatement of METH-seeking behavior.ResultsFemale rats had greater METH-induced reinstatement responding compared to male rats following control treatment injections. MOD (compared to the DMSO control) attenuated METH-seeking behavior in male and female rats; however, ALLO only reduced METH-primed responding in females. MOD alone did not induce the reinstatement of METH-seeking behavior.ConclusionsThese results support previous findings that females are more susceptible to stimulant abuse compared to males and ALLO effectively reduced METH-primed reinstatement in females. Further, they illustrate the utility of MOD as a potential agent for prevention of relapse to METH use in both males and females. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Allopregnanolone | en_US |
dc.subject | Methamphetamine | en_US |
dc.subject | Modafinil | en_US |
dc.subject | Rats | en_US |
dc.subject | Reinstatement | en_US |
dc.subject | Sex differences | en_US |
dc.title | Reinstatement of methamphetamine seeking in male and female rats treated with modafinil and allopregnanolone | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Prisinzano, Thomas E. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1016/j.drugalcdep.2011.07.010 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.