dc.contributor.author | Ambler, Brett R. | |
dc.contributor.author | Altman, Ryan A. | |
dc.date.accessioned | 2017-03-08T19:49:35Z | |
dc.date.available | 2017-03-08T19:49:35Z | |
dc.date.issued | 2013-11 | |
dc.identifier.citation | Ambler, B. R., & Altman, R. A. (2013). Copper-Catalyzed Decarboxylative Trifluoromethylation of Allylic Bromodifluoroacetates. Organic Letters, 15(21), 10.1021/ol402780k. http://doi.org/10.1021/ol402780k | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23363 | |
dc.description.abstract | The development of new synthetic fluorination reactions has important implications in medicinal, agricultural and materials chemistries. Given the prevalence and accessibility of alcohols, methods to convert alcohols to trifluoromethanes are desirable. However, this transformation typically requires four-step processes, specialty chemicals, and/or stoichiometric metals to access the trifluoromethyl-containing product. A two-step copper-catalyzed decarboxylative protocol for converting allylic alcohols to trifluoromethanes is reported. Preliminary mechanistic studies distinguish this reaction from previously reported Cu-mediated reactions. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.title | Copper-Catalyzed Decarboxylative Trifluoromethylation of Allylic Bromodifluoroacetates | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Ambler, Brett R. | |
kusw.kuauthor | Altman, Ryan A. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1021/ol402780k | en_US |
dcterms.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol402780k | |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |