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dc.contributor.authorQiao, Yupu
dc.contributor.authorZhu, Lingui
dc.contributor.authorAmbler, Brett R.
dc.contributor.authorAltman, Ryan A.
dc.date.accessioned2017-03-01T21:06:02Z
dc.date.available2017-03-01T21:06:02Z
dc.date.issued2015-01-01
dc.identifier.citationQiao, Yupu, Lingui Zhu, Brett Ambler, and Ryan Altman. "Decarboxylative Fluorination Strategies for Accessing Medicinally- Relevant Products." Current Topics in Medicinal Chemistry 14.7 (2014): 966-78.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23322
dc.description.abstractFluorinated organic compounds have a long history in medicinal chemistry, and synthetic methods to access target fluorinated compounds are undergoing a revolution. One powerful strategy for the installation of fluorine-containing functional groups includes decarboxylative reactions. Benefits of decarboxylative approaches potentially include: 1) readily available substrates or reagents 2) mild reaction conditions; 3) simplified purification. This focus review highlights the applications of decarboxylation strategies for fluorination reactions to access compounds with biomedical potential. The manuscript highlights on two general strategies, fluorination by decarboxylative reagents and by decarboxylation of substrates. Where relevant, examples of medicinally useful compounds that can be accessed using these strategies are highlighted.en_US
dc.publisherBentham Science Publishersen_US
dc.subjectDecarboxylationen_US
dc.subjectFluorinationen_US
dc.subjectDifluoromethylationen_US
dc.subjectTrifluoromethylationen_US
dc.subjectCopperen_US
dc.titleDecarboxylative Fluorination Strategies for Accessing Medicinally-relevant Productsen_US
dc.typeArticleen_US
kusw.kuauthorAltman, Ryan A.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.2174/1568026614666140202210850en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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