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Motor Function and Dopamine Release Measurements in Transgenic Huntington’s Disease Model Rats

dc.contributor.authorOritz, Andrea N.
dc.contributor.authorOsterhaus, Gregory L.
dc.contributor.authorLauderdale, Kelli
dc.contributor.authorMahoney, Luke
dc.contributor.authorFowler, Stephen C.
dc.contributor.authorvon Hörsten, Stephan
dc.contributor.authorRiess, Olaf
dc.contributor.authorJohnson, Michael A.
dc.date.accessioned2017-02-20T21:52:03Z
dc.date.available2017-02-20T21:52:03Z
dc.date.issued2012-02-24
dc.identifier.citationOrtiz, Andrea N., Gregory L. Osterhaus, Kelli Lauderdale, Luke Mahoney, Stephen C. Fowler, Stephan Von Hörsten, Olaf Riess, and Michael A. Johnson. "Motor Function and Dopamine Release Measurements in Transgenic Huntington's Disease Model Rats." Brain Research 1450 (2012): 148-56.en_US
dc.identifier.urihttp://hdl.handle.net/1808/23203
dc.description.abstractHuntington’s disease (HD) is a fatal, genetic, neurodegenerative disorder characterized by deficits in motor and cognitive function. Here, we have quantitatively characterized motor deficiencies and dopamine release dynamics in transgenic HD model rats. Behavioral analyses were conducted using a newly-developed force-sensing runway and a previously-developed force-plate actometer. Gait disturbances were readily observed in transgenic HD rats at 12 to 15 months of age. Additionally, dopamine system challenge by ip injection of amphetamine also revealed that these rats were resistant to the expression of focused stereotypy compared to wild-type controls. Moreover, dopamine release, evoked by the application of single and multiple electrical stimulus pulses applied at different frequencies, and measured using fast-scan cyclic voltammetry at carbon-fiber microelectrodes, was diminished in transgenic HD rats compared to age-matched wild-type control rats. Collectively, these results underscore the potential contribution of dopamine release alterations to the expression of motor impairments in transgenic HD rats.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectDopamineen_US
dc.subjectHuntington's diseaseen_US
dc.subjectMicroelectrodesen_US
dc.subjectVoltammertryen_US
dc.subjectBehavioren_US
dc.subjectTransgenicen_US
dc.titleMotor Function and Dopamine Release Measurements in Transgenic Huntington’s Disease Model Ratsen_US
dc.typeArticleen_US
kusw.kuauthorFowler, Stephen C.
kusw.kudepartmentPharmacology & Toxicologyen_US
dc.identifier.doi10.1016/j.brainres.2012.02.042en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.