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Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats
dc.contributor.author | Franklin, Jade M. | |
dc.contributor.author | Mathew, Matt | |
dc.contributor.author | Carrasco, Gonzalo A. | |
dc.date.accessioned | 2017-02-16T19:57:10Z | |
dc.date.available | 2017-02-16T19:57:10Z | |
dc.date.issued | 2013-08-26 | |
dc.identifier.citation | Franklin, J. M., Mathew, M., & Carrasco, G. A. (2013). Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. Neuroscience Letters, 548, 165–169. http://doi.org/10.1016/j.neulet.2013.05.039 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23194 | |
dc.description.abstract | Recent behavioral reports suggest that repeated exposure to cannabis and synthetic cannabinoid agonists is linked with mental disorders associated with dysfunction of serotonin 2A (5-HT2A) receptor neurotransmission such as anxiety and depression. Here, we studied the effect of a nonselective cannabinoid agonist, CP55940, on the activity of 5-HT2A receptors in hypothalamic paraventricular nucleus (PVN). We detected that repeated exposure to CP55940 enhanced the prolactin and corticosterone neuroendocrine responses mediated by 5-HT2A receptors and increased the membrane-associated levels of 5-HT2A receptors in PVN. Importantly, we also detected increased anxiety-like behaviors in CP55940 treated rats compared to controls. The data presented here suggest that the mechanisms mediating the cannabinoid-induced upregulation of 5-HT2A receptors would be brain-region specific, as we were unable to detect a CP55940-induced upregulation of 5-HT2A mRNA. Our results might provide insight into the molecular mechanism by which repeated exposure to cannabinoids could be associated with the pathophysiology of neuropsychiatric disorders. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Marijuana | en_US |
dc.subject | Serotonin | en_US |
dc.subject | Hypothalamus | en_US |
dc.subject | 5-HT2A receptor | en_US |
dc.subject | G-proteins | en_US |
dc.title | Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Franklin, Jade M. | |
kusw.kuauthor | Mathew, Matt | |
kusw.kuauthor | Carrasco, Gonzalo A. | |
kusw.kudepartment | Pharmacology and Toxicology | en_US |
dc.identifier.doi | 10.1016/j.neulet.2013.05.039 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.