Show simple item record

dc.contributor.authorFranklin, Jade M.
dc.contributor.authorMathew, Matt
dc.contributor.authorCarrasco, Gonzalo A.
dc.date.accessioned2017-02-16T19:57:10Z
dc.date.available2017-02-16T19:57:10Z
dc.date.issued2013-08-26
dc.identifier.citationFranklin, J. M., Mathew, M., & Carrasco, G. A. (2013). Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. Neuroscience Letters, 548, 165–169. http://doi.org/10.1016/j.neulet.2013.05.039en_US
dc.identifier.urihttp://hdl.handle.net/1808/23194
dc.description.abstractRecent behavioral reports suggest that repeated exposure to cannabis and synthetic cannabinoid agonists is linked with mental disorders associated with dysfunction of serotonin 2A (5-HT2A) receptor neurotransmission such as anxiety and depression. Here, we studied the effect of a nonselective cannabinoid agonist, CP55940, on the activity of 5-HT2A receptors in hypothalamic paraventricular nucleus (PVN). We detected that repeated exposure to CP55940 enhanced the prolactin and corticosterone neuroendocrine responses mediated by 5-HT2A receptors and increased the membrane-associated levels of 5-HT2A receptors in PVN. Importantly, we also detected increased anxiety-like behaviors in CP55940 treated rats compared to controls. The data presented here suggest that the mechanisms mediating the cannabinoid-induced upregulation of 5-HT2A receptors would be brain-region specific, as we were unable to detect a CP55940-induced upregulation of 5-HT2A mRNA. Our results might provide insight into the molecular mechanism by which repeated exposure to cannabinoids could be associated with the pathophysiology of neuropsychiatric disorders.en_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMarijuanaen_US
dc.subjectSerotoninen_US
dc.subjectHypothalamusen_US
dc.subject5-HT2A receptoren_US
dc.subjectG-proteinsen_US
dc.titleCannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in ratsen_US
dc.typeArticleen_US
kusw.kuauthorFranklin, Jade M.
kusw.kuauthorMathew, Matt
kusw.kuauthorCarrasco, Gonzalo A.
kusw.kudepartmentPharmacology and Toxicologyen_US
dc.identifier.doi10.1016/j.neulet.2013.05.039en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.