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Cytotoxic Oleanane-Type Saponins from Albizia inundata
dc.contributor.author | Zhang, Huaping | |
dc.contributor.author | Samadi, Abbas K. | |
dc.contributor.author | Rao, Karumanchi V. | |
dc.contributor.author | Cohen, Mark S. | |
dc.contributor.author | Timmermann, Barbara N. | |
dc.date.accessioned | 2017-01-11T20:00:27Z | |
dc.date.available | 2017-01-11T20:00:27Z | |
dc.date.issued | 2011-02-11 | |
dc.identifier.citation | Zhang, Huaping, Abbas K. Samadi, Karumanchi V. Rao, Mark S. Cohen, and Barbara N. Timmermann. "Cytotoxic Oleanane-Type Saponins FromAlbizia Inundata." Journal of Natural Products 74.3 (2011): 477-82. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22579 | |
dc.description.abstract | Bioassay-guided fractionation of a CH2Cl2−MeOH extract of the aerial parts of Albizia inundata resulted in the isolation of two new natural oleanane-type triterpene saponins {3-O-[α-l-arabinopyranosyl(1→6)]-2-acetamido-2-deoxy-β-d-glucopyranosyl oleanolic acid (1) and 3-O-[α-l-arabinopyranosyl(1→2)-α-l-arabinopyranosyl(1→6)]-2-acetamido-2-deoxy-β-d-glucopyranosyl acacic acid lactone (2)} along with seven known saponins {3-O-[α-l-arabinopyranosyl(1→6)]-2-acetamido-2-deoxy-β-d-glucopyranosyl echinocystic acid (3), 3-O-[β-d-xylopyranosyl (l→2)-α-l-arabinopyranosyl(l→6)]-2-acetamido-2-deoxy-β-d-glucopyranosyl acacic acid lactone (concinnoside D) (4), 3-O-[β-d-glucopyranosyl(l→2)]-β-d-glucopyranosyl oleanolic acid (5), 3-O-[α-l-arabinopyranosyl(1→2)-α-l-arabinopyranosyl(l→6)]-β-d-glucopyranosyl oleanolic acid (6), 3-O-[β-d-xylopyranosyl(1→2)-α-l-arabinopyranosyl(l→6)]-β-d-glucopyranosyl oleanolic acid (7), 3-O-[α-l-arabinopyranosyl(l→2)-α-l-arabinopyranosyl(1→6)-[β-d-glucopyranosyl(l→2)]-β-d-glucopyranoside echinocystic acid (8), and 3-O-[β-d-xylopyranosyl(l→2)-α-l-arabinopyranosyl(1→6)-[β-d-glucopyranosyl(l→2)]-β-d-glucopyranoside echinocystic acid (9)}. The structures of 1 and 2 were established on the basis of extensive 2D NMR (1H−1H COSY or DQF-COSY, HSQC, HMBC, TOCSY, and HSQC-TOCSY) spectroscopic, ESIMS, and chemical methods. Saponins 1, 3, 6, and 7 showed cytotoxicity against human head and neck squamous cells (JMAR, MDA1986) and melanoma cells (B16F10, SKMEL28) with IC50 values in the range 1.8−12.4 μM, using the MTS assay. | en_US |
dc.publisher | Journal of Natural Products | en_US |
dc.rights | Copyright © 2011 The American Chemical Society and American Society of Pharmacognosy | en_US |
dc.title | Cytotoxic Oleanane-Type Saponins from Albizia inundata | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Timmermann, Barbara N. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1021/np100702p | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |