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    Maternal DHA Supplementation and Childhood Blood Pressure

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    Hilton_ku_0099M_14546_DATA_1.pdf (1.019Mb)
    Issue Date
    2016-05-31
    Author
    Hilton, Jamie
    Publisher
    University of Kansas
    Format
    55 pages
    Type
    Thesis
    Degree Level
    M.S.
    Discipline
    Dietetics & Nutrition
    Rights
    Copyright held by the author.
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    Abstract
    Background: Blood pressure (BP) in childhood is positively associated with BP in adulthood; it is important to understand influential factors of childhood BP. Child race, body mass index (BMI), and diet are well studied, but intrauterine exposures that may influence BP long term are not well explored. Objective: To determine if DHA supplementation during pregnancy leads to lower blood pressure in offspring at 4-5.5 years of age. Methods: We measured BP longitudinally at 6-mo intervals from 4 to 5.5 years of age in a cohort of 179 children whose mothers were randomized to either supplementation with the omega-3 fatty acid DHA (600 mg/d) or placebo during pregnancy. Results: Black race, child BMI and child salt intake were positively associated with systolic and diastolic BP. Maternal DHA status at delivery was associated with significantly lower BP at 4 and 5 years of age. Black children whose mothers were assigned to placebo had higher BP across all ages compared to white children and black children whose mothers were supplemented with DHA. Similarly, maternal DHA supplementation protected against higher BP observed in children who were overweight or obese compared to healthy weight children at 4 and 5 years of age; and protected BP of those whose average sodium intake across all ages exceeded 1.9 g/day. Conclusion: Improving fetal DHA status through maternal DHA supplementation during pregnancy appears to protect against several risk factors for higher BP in childhood.
    URI
    http://hdl.handle.net/1808/22492
    Collections
    • Education Dissertations and Theses [1065]
    • Theses [3828]

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    785-864-8983

    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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