dc.contributor.author | Aldrich, Jane V. | |
dc.contributor.author | Senadheera, Sanjeewa N. | |
dc.contributor.author | Ross, Nicolette C. | |
dc.contributor.author | Ganno, Michelle L. | |
dc.contributor.author | Eans, Shainnel O. | |
dc.contributor.author | McLaughlin, Jay P. | |
dc.date.accessioned | 2017-01-05T19:13:34Z | |
dc.date.available | 2017-01-05T19:13:34Z | |
dc.date.issued | 2013-01-17 | |
dc.identifier.citation | Aldrich, Jane V., Sanjeewa N. Senadheera, Nicolette C. Ross, Michelle L. Ganno, Shainnel O. Eans, and Jay P. Mclaughlin. "The Macrocyclic Peptide Natural Product CJ-15,208 Is Orally Active and Prevents Reinstatement of Extinguished Cocaine-Seeking Behavior." Journal of Natural Products 76.3 (2013): 433-38. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/22463 | |
dc.description.abstract | The macrocyclic tetrapeptide natural product CJ-15,208 (cyclo[Phe-d-Pro-Phe-Trp]) exhibited both dose-dependent antinociception and kappa opioid receptor (KOR) antagonist activity after oral administration. CJ-15,208 antagonized a centrally administered KOR selective agonist, providing strong evidence it crosses the blood–brain barrier to reach KOR in the CNS. Orally administered CJ-15,208 also prevented both cocaine- and stress-induced reinstatement of extinguished cocaine-seeking behavior in the conditioned place preference assay in a time- and dose-dependent manner. Thus, CJ-15,208 is a promising lead compound with a unique activity profile for potential development, particularly as a therapeutic to prevent relapse to drug-seeking behavior in abstinent subjects. | en_US |
dc.publisher | Journal of Natural Products | en_US |
dc.rights | Copyright © 2013 The American Chemical Society and American Society of Pharmacognosy | en_US |
dc.title | The Macrocyclic Peptide Natural Product CJ-15,208 Is Orally Active and Prevents Reinstatement of Extinguished Cocaine-Seeking Behavior | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Aldrich, Jane V. | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1021/np300697k | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | |