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    Immunoendocrine interactions and T cell proliferation responses to layered physical and psychological stressors

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    Siedlik_ku_0099D_14496_DATA_1.pdf (7.827Mb)
    Issue Date
    2016-05-31
    Author
    Siedlik, Jacob Andrew
    Publisher
    University of Kansas
    Format
    229 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Health, Sport and Exercise Sciences
    Rights
    Copyright held by the author.
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    Abstract
    Introduction: Military training environments are rigorous requiring service men and women to endure not only physical and psychological stress but also sleep deprivation, caloric restrictions, and severe thermic challenges. Exposure to these layered stressors are thought to improve human performance by acclimating the individuals to “real-world” operational stressors. It is difficult for scientists to identify pertinent immunoendocrine interactions occurring in layered stress environments because of considerable logistical constraints involving location of and access to affected personnel. The convention has been to use immunoendocrine responses induced by various exercise regimens as platforms to generalize results to the layered, and more exaggerated stress environments of military training. Methods: Three distinct experiments were conducted to understand immunoendocrine interactions resulting from layered stress environments. The first project investigated T cell proliferation following concurrent aerobic and resistance training as well as assessing changes in measures of proliferation following delayed cell isolation protocols. The second project examined whether the exercise models we use to generalize to military experiences are accurate. Eight healthy males underwent a high intensity training session combining physical and psychological stress similar to that experience in military operational training. A control group of 8 subjects participated in a moderate intensity session as comparison. Blood parameters were measured at Pre, Post, 1 hr, 4hr, and 6hr. The third project was an observational study examining immunoendocrine responses to the Marine Corps Martial Arts Training Program (MCMAP). Thirty-six newly enlisted, male Marines were observed three times over a nine-week period at Fort Leonard Wood, MO. Blood parameters were measured prior to training, Post training and at 15 min intervals out to 1 hr after training cessation. Conclusions: Immunoendocrine alterations following MCMAP sessions are in line with current laboratory findings that examine response to paired physical and psychological stressors suggesting MCMAP may be a good real world analogue of laboratory based layered stress experiments. The higher intensity training sessions utilized in study two generated an enhanced proliferative response similar to that observed from exercise in competitive settings suggestive of a psychologically driven mechanism for proliferation.
    URI
    http://hdl.handle.net/1808/21993
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    • Dissertations [4475]
    • Education Dissertations and Theses [1065]

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    785-864-8983
    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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