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SERUM S100 PROTEINS AS A MARKER OF DISEASE ACTIVITY IN LARGE VESSEL VASULITIS
dc.contributor.advisor | Ellerbeck, Edward | |
dc.contributor.author | Springer, Jason Michael | |
dc.date.accessioned | 2016-11-11T00:22:27Z | |
dc.date.available | 2016-11-11T00:22:27Z | |
dc.date.issued | 2015-12-31 | |
dc.date.submitted | 2015 | |
dc.identifier.other | http://dissertations.umi.com/ku:14403 | |
dc.identifier.uri | http://hdl.handle.net/1808/21929 | |
dc.description.abstract | Objectives: Serum S100A8/S100A9 and S100A12 levels have been shown to be elevated in giant cell arteritis (GCA). This study aimed to determine if levels of serum S100 proteins perform as markers in a comparable fashion to standard markers of disease activity in large-vessel vasculitis. Methods: Serum samples were obtained from the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Study of GCA and Takayasu’s arteritis (TAK). A mixed effects model compared S100 proteins during active and inactive disease states. Receiver operating characteristic curves compared models using S100 proteins to models using ESR and CRP. Results: There were 106 samples (50 during active disease) from patients with GCA and 32 samples (16 during active disease) from patients with TAK. In GCA, S100A8/S100A9 and S100A12 were significantly elevated during active disease (2150 ng/mL vs. 2020 ng/mL, p = 0.003;150 ng/mL vs. 130ng/mL, p=0.016, respectively). There were weak correlations between levels of S100 proteins and ESR or CRP. A model including S100A8/S100A9, S100A12, ESR, and CRP was a better indicator of disease activity compared to ESR and CRP together. In TAK, there were no significant differences between active and inactive disease for either the S100 proteins or ESR/CRP. Conclusions: Serum levels of S100A8/S100A9 and S100A12 are elevated during active disease and perform comparably to ESR and CRP as measures of disease activity in giant cell arteritis. | |
dc.format.extent | 20 pages | |
dc.language.iso | en | |
dc.publisher | University of Kansas | |
dc.rights | Copyright held by the author. | |
dc.subject | Medicine | |
dc.subject | Giant Cell Arteritis | |
dc.subject | Large Vessel Vasculitis | |
dc.subject | S100 proteins | |
dc.subject | Takayasu's Arteritis | |
dc.title | SERUM S100 PROTEINS AS A MARKER OF DISEASE ACTIVITY IN LARGE VESSEL VASULITIS | |
dc.type | Thesis | |
dc.contributor.cmtemember | Maz, Mehrdad | |
dc.contributor.cmtemember | Dileepan, Kottarappat N | |
dc.thesis.degreeDiscipline | Preventive Medicine and Public Health | |
dc.thesis.degreeLevel | M.S. | |
dc.identifier.orcid | ||
dc.rights.accessrights | openAccess |
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KU Med Center Dissertations and Theses [464]
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Theses [4088]