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dc.contributor.advisorEllerbeck, Edward
dc.contributor.authorSpringer, Jason Michael
dc.date.accessioned2016-11-11T00:22:27Z
dc.date.available2016-11-11T00:22:27Z
dc.date.issued2015-12-31
dc.date.submitted2015
dc.identifier.otherhttp://dissertations.umi.com/ku:14403
dc.identifier.urihttp://hdl.handle.net/1808/21929
dc.description.abstractObjectives: Serum S100A8/S100A9 and S100A12 levels have been shown to be elevated in giant cell arteritis (GCA). This study aimed to determine if levels of serum S100 proteins perform as markers in a comparable fashion to standard markers of disease activity in large-vessel vasculitis. Methods: Serum samples were obtained from the Vasculitis Clinical Research Consortium (VCRC) Longitudinal Study of GCA and Takayasu’s arteritis (TAK). A mixed effects model compared S100 proteins during active and inactive disease states. Receiver operating characteristic curves compared models using S100 proteins to models using ESR and CRP. Results: There were 106 samples (50 during active disease) from patients with GCA and 32 samples (16 during active disease) from patients with TAK. In GCA, S100A8/S100A9 and S100A12 were significantly elevated during active disease (2150 ng/mL vs. 2020 ng/mL, p = 0.003;150 ng/mL vs. 130ng/mL, p=0.016, respectively). There were weak correlations between levels of S100 proteins and ESR or CRP. A model including S100A8/S100A9, S100A12, ESR, and CRP was a better indicator of disease activity compared to ESR and CRP together. In TAK, there were no significant differences between active and inactive disease for either the S100 proteins or ESR/CRP. Conclusions: Serum levels of S100A8/S100A9 and S100A12 are elevated during active disease and perform comparably to ESR and CRP as measures of disease activity in giant cell arteritis.
dc.format.extent20 pages
dc.language.isoen
dc.publisherUniversity of Kansas
dc.rightsCopyright held by the author.
dc.subjectMedicine
dc.subjectGiant Cell Arteritis
dc.subjectLarge Vessel Vasculitis
dc.subjectS100 proteins
dc.subjectTakayasu's Arteritis
dc.titleSERUM S100 PROTEINS AS A MARKER OF DISEASE ACTIVITY IN LARGE VESSEL VASULITIS
dc.typeThesis
dc.contributor.cmtememberMaz, Mehrdad
dc.contributor.cmtememberDileepan, Kottarappat N
dc.thesis.degreeDisciplinePreventive Medicine and Public Health
dc.thesis.degreeLevelM.S.
dc.identifier.orcid
dc.rights.accessrightsopenAccess


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