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dc.contributor.authorMosconi, Matthew W.
dc.contributor.authorSweeny, John A.
dc.date.accessioned2016-08-03T16:09:29Z
dc.date.available2016-08-03T16:09:29Z
dc.date.issued2015-10
dc.identifier.citationMosconi MW, Sweeney JA. Sensorimotor dysfunctions as primary features of autism spectrum disorders. Sci China Life Sci, 2015, 58: 1016–1023, doi: 10.1007/s11427-015-4894-4en_US
dc.identifier.urihttp://hdl.handle.net/1808/21251
dc.description.abstractMotor impairments in autism spectrum disorders (ASD) have received far less research attention than core social-communication and cognitive features. Yet, behavioral, neurophysiological, neuroimaging and histopathological studies have documented abnormal motor system development in the majority of individuals with ASD suggesting that these deficits may be primary to the disorder. There are several unique advantages to studying motor development in ASD. First, the neurophysiological substrates of motor skills have been well-characterized via animal and human lesion studies. Second, many of the single- gene disorders associated with ASD also are characterized by motor dysfunctions. Third, recent evidence suggests that the onset of motor dysfunctions may precede the emergence of social and communication deficits during the first year of life in ASD. Motor deficits documented in ASD indicate disruptions throughout the neuroaxis affecting cortex, striatum, the cerebellum and brainstem. Questions remain regarding the timing and development of motor system alterations in ASD, their association with defining clinical features, and their potential for parsing heterogeneity in ASD. Pursuing these questions through neurobiologically informed translational research holds great promise for identifying gene-brain pathways associated with ASD.en_US
dc.publisherSpringerOpenen_US
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectAutismen_US
dc.subjectCerebellumen_US
dc.subjectDyspraxiaen_US
dc.subjectMotoren_US
dc.subjectOculomotoren_US
dc.titleSensorimotor dysfunctions as primary features of autism spectrum disordersen_US
dc.typeArticleen_US
kusw.kuauthorMosconi, Matthew W.
kusw.kudepartmentApplied Behavioral Scienceen_US
dc.identifier.doi10.1007/s11427-015-4894-4en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccess


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.