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    Inhibition of Runx by Ro5-3335 Affects Nematostella Regeneration

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    TranChristina_Nematostella.pdf (240.9Kb)
    Issue Date
    2016-01-25
    Author
    Tran, Christina
    Publisher
    Department of Ecology & Evolutionary Biology, University of Kansas
    Type
    Undergraduate research project
    Article Version
    Scholarly/refereed, publisher version
    Discipline
    Ecology and Evolutionary Biology
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    Abstract
    The sea anemone, Nematostella vectensis, has the ability to fully regenerate amputated body parts. We hypothesize that Runx, a transcription factor, controls the cellular processes for regeneration, specifically the transition between cellular proliferation and cellular differentiation. A known inhibitor to the Runx pathway is Ro5-3335, a benzodiazepine. Inhibiting the Runx pathway by Ro5-3335 will help determine if Runx is necessary for proper regeneration in Nematostella. We introduced bisected Nematostella polyps to Ro5-3335 for a 24-48 period and observed regeneration of oral ends. Tentacle regeneration appeared delayed in treated polyps compared to the controls. It was not until three weeks post-treatment that the treated animals recovered normal regeneration. We conclude that Ro5-3335 appears to repress regeneration in the polyps which suggests that the Runx pathway is important for proper regeneration in Nematostella.
    Description
    This undergraduate research project is being made available in KU ScholarWorks with the permission of the author. The project was supervised by Dr. Paulyn Cartwright, associate professor of Ecology and Evolutionary Biology at the University of Kansas.
    URI
    http://hdl.handle.net/1808/21021
    Collections
    • Undergraduate Research, including Senior Theses [63]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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