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dc.contributor.authorWecht, Jill M.
dc.contributor.authorWeir, Joseph P.
dc.contributor.authorRadulovic, Miroslav
dc.contributor.authorBauman, William A.
dc.identifier.citationJ. M. Wecht, J. P. Weir, M. Radulovic, W. A. Bauman. Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls. Physiol Rep, 4 (3), 2016, e12683, doi: 10.14814/phy2.12683en_US
dc.descriptionThis is the published version.en_US
dc.description.abstractWe previously showed that increases in mean arterial pressure (MAP) following administration of midodrine hydrochloride (MH) and nitro-L-arginine methyl ester (L-NAME) resulted in increased mean cerebral blood flow velocity (MFV) during head-up tilt in hypotensive individuals with spinal cord injury (SCI) and question if this same association was evident during cognitive activation. Herein, we report MAP and MFV during two serial subtraction tasks (SSt) given before (predrug) and after (postdrug) administration of MH; (10 mg), L-NAME (1 mg/kg) or no drug (ND) in 15 subjects with SCI compared to nine able-bodied (AB) controls. Three-way factorial analysis of variance (ANOVA) models were used to determine significant main and interaction effects for group (SCI, AB), visit (MH, L-NAME, ND), and time (predrug, postdrug) for MAP and MFV during the two SSt. The three-way interaction was significant for MAP (F = 4.262; P = 0.020); both MH (30 ± 26 mmHg; P < 0.05) and L-NAME (27 ± 22 mmHg; P < 0.01) significantly increased MAP in the SCI group, but not in the AB group. There was a significant visit by time interaction for MFV suggesting an increase from predrug to postdrug following L-NAME (6 ± 8 cm/sec; P < 0.05) and MH (4 ± 7 cm/sec; P < 0.05), regardless of study group, with little change following ND (3 ± 3 cm/sec). The relationship between change in MAP and MFV was significant in the SCI group following administration of MH (r2 = 0.38; P < 0.05) and L-NAME (r2 = 0.32; P < 0.05). These antihypotensive agents, at the doses tested, raised MAP, which was associated with an increase MFV during cognitive activation in hypotensive subjects with SCI.en_US
dc.publisherWiley Open Accessen_US
dc.titleEffects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controlsen_US
kusw.kuauthorWeir, Joseph
kusw.kudepartmentHealth, Sport, & Exercise Sciencesen_US
kusw.oanotesPer SHERPA/RoMEO, 5/19/2016: Author's Pre-print: question mark archiving status unclear Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF General Conditions:

Creative Commons Attribution License Authors retain copyright On open access repositories and any website Hosting site must incorporate publisher-supplied amendments or retractions issued Published source must be acknowledged including article DOI Articles published prior to 14 August 2012, are published under a Creative Commons Attribution Non-Commercial License or another License Publisher's version/PDF may be used
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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