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    Metabolic Syndrome and Cognitive Decline in Early Alzheimer’s Disease and Healthy Older Adults

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    Issue Date
    2013-01
    Author
    Watts, Amber
    Loskutova, Natalia Y.
    Burns, Jeffrey M.
    Johnson, David K.
    Publisher
    IOS Press
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Metabolic syndrome (MetS) is a cluster of risk factors (i.e., abdominal obesity, hypertension, dyslipidemia, glucose and insulin dysregulation) that is associated with cardiovascular disease, diabetes, and dementia. Recent studies addressing the association of MetS with cognitive performance and risk for dementia report mixed results. An important step in clarifying these conflicting results is determining whether cognition is influenced by the effects of individual MetS components versus the additive effects of multiple components. We assessed the effect of MetS on cognitive performance and decline over two years in 75 cases of early Alzheimer’s disease (AD) and 73 healthy older adult controls in the Brain Aging Project. Using factor analytic techniques, we compared the effect of a combined MetS factor to the effect of individual MetS components on change in attention, verbal memory, and mental status. In healthy controls, a combined MetS factor did not significantly predict cognitive performance, though higher insulin predicted poorer cognitive performance outcomes. In the AD group, higher scores on a combined MetS factor predicted better cognitive outcomes. Our findings suggest that MetS does not have the same association with cognitive decline in healthy older adults and those with early AD. We suggest that individual MetS components should not be evaluated in isolation and that careful methodological approaches are needed to understand the timing and non-linear relationships among these components over time.
    Description
    This is the author's accepted manuscript. The original is available at http://content.iospress.com/articles/journal-of-alzheimers-disease/jad121168
    URI
    http://hdl.handle.net/1808/20548
    DOI
    https://doi.org/10.3233/JAD-121168
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    • Psychology Scholarly Works [246]
    Citation
    Watts, Amber S., Natalia Loskutova, Jeffrey M. Burns, and David K. Johnson. "Metabolic Syndrome and Cognitive Decline in Early Alzheimer’s Disease and Healthy Older Adults." Journal of Alzheimer's Disease (2013): 253-65. http://dx.doi.org/10.3233/JAD-121168

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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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