Neuropsychiatric Profiles in Dementia
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Issue Date
2011-10Author
Johnson, David K.
Watts, Amber
Chapin, Benjamin A.
Anderson, RaeAnn
Burns, Jeffrey M.
Publisher
Lippincott, Williams & Wilkins
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Metadata
Show full item recordAbstract
We compared patterns of neuropsychiatric symptom across four dementia types (AD, VAD, DLB, PDD), and two mixed groups (AD/VAD, AD/DLB) in sample of 2,963 individuals from the National Alzheimer’s Coordinating Center Uniform Data Set between September 2005 and June 2008. We used confirmatory factor analysis to compare neuropsychiatric symptom severity ratings made by collateral sources on the Neuropsychiatric Inventory (NPI-Q) for people with Clinical Dementia Rating scores of 1 or higher. A three factor model of psychiatric symptoms (mood, psychotic, and frontal) was shared across all dementia types. Between-group comparisons revealed unique neuropsychiatric profiles by dementia type. The AD group had moderate levels of mood, psychotic, and frontal symptoms while VAD exhibited the highest levels and PDD had the lowest levels. DLB and the mixed dementias had more complex symptom profiles. Depressed mood was the dominant symptom in people with mild diagnoses. Differing psychiatric symptom profiles provide useful information regarding the non-cognitive symptoms of dementia.
Description
This is the author's accepted manuscript. The original is available at http://pt.wkhealth.com/pt/re/lwwgateway/landingpage.htm;jsessionid=Wy1M9PqrBY1LGf0bN3QqF0h42YJqr4mTnW1ZdGT87Wllb4qvTbQb!-396536289!181195628!8091!-1?sid=WKPTLP:landingpage&an=00002093-201110000-00006
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Citation
Johnson, David K., Amber Watts, and Jeffrey M. Burns. "Neuropsychiatric Profiles of Dementia." Alzheimer's & Dementia 6.4 (2010): n. pag. http://dx.doi.org/10.1097/WAD.0b013e31820d89b6
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