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    Reduced Lean Mass in Early Alzheimer Disease and Its Association With Brain Atrophy

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    Issue Date
    2010-04
    Author
    Burns, Jeffrey M.
    Johnson, David K.
    Watts, Amber
    Swerdlow, Russell Howard
    Brooks, William M.
    Publisher
    American Medical Association
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    Objective: To examine body composition in individuals with early AD and without dementia and its relation to cognition and brain volume.

    Design: Cross-sectional case-control study.

    Participants: Individuals without dementia (Clinical Dementia Rating, 0; n=70) and with early-stage AD (Clinical Dementia Rating, 0.5 or 1; n=70) in the Alzheimer and Memory Program at the University of Kansas School of Medicine.

    Main Outcome Measures: Participants were evaluated with brain magnetic resonance imaging (MRI), neuropsychological testing, and dual-energy x-ray absorptiometry to determine whole-body fat and lean masses. Body mass index was calculated as weight in kilograms divided by height in meters squared.

    Results: Lean mass was reduced in persons with early AD compared with controls without dementia (F=7.73; P=.006) after controlling for sex. Whole-brain volume (=.20; P.001), white matter volume (=.19; P.001), and global cognitive performance (=.12; P=.007) were associated with lean mass (dependent variable) when controlling for age and sex. The total body fat and percentage of body fat values were not different across groups or related to cognition and brain volume.

    Conclusion: Loss of lean mass is accelerated in AD and is associated with brain atrophy and cognitive performance, perhaps as a direct or indirect consequence of AD pathophysiology or through shared mechanisms common to both AD and sarcopenia.
    Description
    This is the published version. Copyright American Medical Association
    URI
    http://hdl.handle.net/1808/20540
    DOI
    https://doi.org/10.1001/archneurol.2010.38
    Collections
    • Psychology Scholarly Works [272]
    Citation
    Burns, Jeffrey M., David K. Johnson, Amber Watts, Russell H. Swerdlow, and William M. Brooks. "Reduced Lean Mass in Early Alzheimer Disease and Its Association With Brain Atrophy." Arch Neurol Archives of Neurology 67.4 (2010): n. pag. http://dx.doi.org/10.1001/archneurol.2010.38

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    KU Libraries
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    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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