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dc.contributor.authorWatts, Amber
dc.contributor.authorHonea, Robyn A.
dc.contributor.authorBillinger, Sandra A.
dc.contributor.authorRhyner, Kathleen
dc.contributor.authorHutfles, Lewis
dc.contributor.authorVidoni, Eric D.
dc.contributor.authorBurns, Jeffrey M.
dc.identifier.citationWatts, Amber, Robyn A. Honea, Sandra A. Billinger, Kathleen T. Rhyner, Lewis Hutfles, Eric D. Vidoni, and Jeffrey M. Burns. "A Combined Measure of Vascular Risk for White Matter Lesions." Journal of Pharmaceutical Sciences (2015): 187-93. doi:10.3233/JAD-142085.en_US
dc.descriptionThis is the author's accepted manuscript.en_US

Though hypertension is a commonly studied risk factor for white matter lesions (WMLs), measures of blood pressure may fluctuate depending on external conditions resulting in measurement error. Indicators of arterial stiffening and reduced elasticity may be more sensitive indicators of risk for WMLs in aging; however the interdependent nature of vascular indicators creates statistical complications. Objective

The purpose of the study was to determine whether a factor score comprised of multiple vascular indicators would be a stronger predictor of WMLs than traditional measures of blood pressure. Methods

In a sample of well-characterized nondemented older adults, we used a factor analytic approach to account for variance common across multiple vascular measures while reducing measurement error. The result was a single factor score reflecting arterial stiffness and reduced elasticity. We used this factor score to predict white matter lesion volumes acquired via fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging. Results

The combined vascular factor score was a stronger predictor of deep WML (β = 0.42, p < 0.001) and periventricular WML volumes (β = 0.49, p < 0.001). After accounting for the vascular factor, systolic and diastolic blood pressure measurements were not significant predictors. Conclusions

This suggests that a combined measure of arterial elasticity and stiffening may be a stronger predictor of WMLs than systolic and diastolic blood pressure accounting for the multicollinearity associated with a variety of interrelated vascular measures.
dc.subjectArterial stiffnessen_US
dc.subjectFactor analysisen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectVascular elasticityen_US
dc.subjectWhite matter lesionsen_US
dc.titleA Combined Measure of Vascular Risk for White Matter Lesionsen_US
kusw.kuauthorWatts, Amber
kusw.oaversionScholarly/refereed, author accepted manuscript
kusw.oapolicyThis item meets KU Open Access policy criteria.

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