KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Dissertations and Theses
    • Dissertations
    • View Item
    •   KU ScholarWorks
    • Dissertations and Theses
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The Regulation of a Pathogenic Macrophage Polarization by IL-10 in Polycystic Kidney Disease

    Thumbnail
    View/Open
    Peda_ku_0099D_14298_DATA_1.pdf (12.00Mb)
    Issue Date
    2015-12-31
    Author
    Peda, Jacqueline Dawn
    Publisher
    University of Kansas
    Format
    111 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Pathology & Laboratory Medicine
    Rights
    Copyright held by the author.
    Metadata
    Show full item record
    Abstract
    Polycystic kidney disease (PKD) is a devastating genetic disorder that is one of the most common potentially fatal inherited diseases and is the fourth leading cause of end-stage renal disease (ESRD) in the US5,6,7. The most common form of the disease, autosomal dominant PKD (ADPKD) affects up to 1 in 500 and costs $2 billion/year to care for those afflicted. As the name implies, PKD is characterized by the presence of large, fluid-filled cysts that expand within the kidney, distorting and damaging parenchyma and ultimately resulting in loss of kidney function. Currently, there are no FDA-approved treatments for PKD, but there is hope that a thorough understanding of disease pathogenesis will facilitate the development of treatment strategies that target key drivers of disease progression. In this dissertation, I will summarize what is known about clinical and pathologic features of the disease, focusing on ADPKD and a previously underappreciated aspect of disease pathophysiology—the role of inflammation, especially involving innate immune cells known as macrophages. This work will then describe details of investigations undertaken to better understand the genesis of pathologic macrophages in the cystic kidney and their role in disease progression. These studies have revealed the regulatory cytokine IL-10 to play a key role in this process and thus have identified that cytokine and its signaling partners as potential targets for therapeutic intervention in PKD.
    URI
    http://hdl.handle.net/1808/19473
    Collections
    • Dissertations [3958]

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps