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dc.contributor.advisorShireman, Theresa Ien_US
dc.contributor.authorUysal, Utku
dc.date.accessioned2016-01-02T17:13:45Z
dc.date.available2016-01-02T17:13:45Z
dc.date.issued2015-05-31en_US
dc.date.submitted2015en_US
dc.identifier.otherhttp://dissertations.umi.com/ku:13969en_US
dc.identifier.urihttp://hdl.handle.net/1808/19458en_US
dc.description.abstractObjective: To determine factors associated with continuous IV anesthetic drug (IVAD) use in nonconvulsive status epilepticus (NCSE). Methods: For this retrospective descriptive cohort study, we included all patients who met clinical and EEG criteria of NCSE from 2009 to 2014 at a tertiary academic medical center. Patients were categorized according to IVAD use. Primary outcome variables were response to treatment and in-hospital death. We used descriptive analyses for baseline characteristics, and primary and secondary outcome variables differences among patients who received IVAD and who did not receive IVAD. Results: Forty-three patients had a total of 45 NCSE episodes. IVAD was used in 69% of the episodes. Patients treated with IVAD were younger (53.1±14.1 vs 64.1±13.3, p=0.0187). The episodes treated with IVAD were associated with more acute neurologic pathology (58% vs 21%, p=0.0236) and more commonly presenteded in comatose patients (39% vs 7%, p=0.0299). Underlying epilepsy was common in both groups (36% in IVAD vs 42% in no-IVAD group). NCSE resolved in 74% of the patients who received IVAD. There were total 13 in-hospital deaths (ten in IVAD users vs three in the no-IVAD group). Only one in-hospital death appeared to be a direct consequence of IVAD. Conclusion: Our findings showed factors such as younger age, acute neurologic pathology and coma at presentation were associated with IVAD use in patients with NCSE. More patients died in IVAD group although this was not statistically significant. There is a need of further studies to determine the effect of IVAD use in NCSE on outcome, and these factors should be controlled in the future outcome and effectiveness studies.
dc.format.extent28 pagesen_US
dc.language.isoen_USen_US
dc.publisherUniversity of Kansasen_US
dc.rightsCopyright held by the author.en_US
dc.subjectMedicine
dc.subjectAnesthetic drugs
dc.subjectAntiepileptic drugs
dc.subjectBenzodiasepines
dc.subjectNonconvulsive status epilepticus
dc.subjectStatus Epilepticus
dc.titleCLINICAL CORRELATES OF INTRAVENOUS ANESTHETIC DRUG USE
dc.typeThesisen_US
dc.contributor.cmtememberEllerbeck, Edward
dc.contributor.cmtememberGronseth, Gary
dc.thesis.degreeDisciplineClinical Research
dc.thesis.degreeLevelM.S.
dc.rights.accessrightsopenAccessen_US


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