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dc.contributor.authorWenzler, Tanja
dc.contributor.authorYang, Sihyung
dc.contributor.authorPatrick, Donald A.
dc.contributor.authorBraissant, Olivier
dc.contributor.authorIsmail, Mohamed A.
dc.contributor.authorTidwell, Richard R.
dc.contributor.authorBoykin, David W.
dc.contributor.authorWang, Zhuo
dc.contributor.authorBrun, Reto
dc.date.accessioned2015-12-31T18:13:09Z
dc.date.available2015-12-31T18:13:09Z
dc.date.issued2014-05-27
dc.identifier.citationWenzler, T., S. Yang, D. A. Patrick, O. Braissant, M. A. Ismail, R. R. Tidwell, D. W. Boykin, M. Z. Wang, and R. Brun. "In Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sickness." Antimicrobial Agents and Chemotherapy 58.8 (2014): 4452-463. http://dx.doi.org/10.1128/AAC.02309-13en_US
dc.identifier.urihttp://hdl.handle.net/1808/19370
dc.descriptionThis is the published version.en_US
dc.description.abstractAfrican sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a dipyridylbenzene analogue of DB829, is the second simple diamidine found to cure mice with central nervous system infections by a parenteral route of administration. 28DAP010 showed efficacy similar to that of DB829 in dose-response studies in mouse models of first- and second-stage African sleeping sickness. The in vitro time to kill, determined by microcalorimetry, and the parasite clearance time in mice were shorter for 28DAP010 than for DB829. No cross-resistance was observed between 28DAP010 and pentamidine on the tested Trypanosoma brucei gambiense isolates from melarsoprol-refractory patients. 28DAP010 is the second promising preclinical candidate among the diamidines for the treatment of second-stage African sleeping sickness.en_US
dc.publisherAmerican Society for Microbiologyen_US
dc.relation.isversionof10.1128/AAC.02309-13en_US
dc.titleIn Vitro and In Vivo Evaluation of 28DAP010, a Novel Diamidine for Treatment of Second-Stage African Sleeping Sicknessen_US
dc.typeArticle
kusw.kuauthorWang, Zhuo
kusw.kudepartmentPharmaceutical Chemistryen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1751-4975
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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