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All motors have to decide is what to do with the DNA that is given them
dc.contributor.author | Briggs, Koan | |
dc.contributor.author | Fischer, Christopher J. | |
dc.date.accessioned | 2015-12-16T17:07:26Z | |
dc.date.available | 2015-12-16T17:07:26Z | |
dc.date.issued | 2014-11 | |
dc.identifier.citation | Briggs, Koan, and Christopher J. Fischer. "All Motors Have to Decide Is What to Do with the DNA That Is given Them." Biomolecular Concepts 5.5 (2014). http://dx.doi.org/10.1515/bmc-2014-0017 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/19201 | |
dc.description | This is the published version. Copyright 2014 De Gruyter. | en_US |
dc.description.abstract | DNA translocases are a diverse group of molecular motors responsible for a wide variety of cellular functions. The goal of this review is to identify common aspects in the mechanisms for how these enzymes couple the binding and hydrolysis of ATP to their movement along DNA. Not surprisingly, the shared structural components contained within the catalytic domains of several of these motors appear to give rise to common aspects of DNA translocation. Perhaps more interesting, however, are the differences between the families of translocases and the potential associated implications both for the functions of the members of these families and for the evolution of these families. However, as there are few translocases for which complete characterizations of the mechanisms of DNA binding, DNA translocation, and DNA-stimulated ATPase have been completed, it is difficult to form many inferences. We therefore hope that this review motivates the necessary further experimentation required for broader comparisons and conclusions. | en_US |
dc.publisher | De Gruyter | en_US |
dc.subject | ATPase | en_US |
dc.subject | Molecular motor | en_US |
dc.subject | Translocase | en_US |
dc.title | All motors have to decide is what to do with the DNA that is given them | en_US |
dc.type | Article | |
kusw.kuauthor | Fischer, Christopher J. | |
kusw.kudepartment | Physics and Astronomy | en_US |
dc.identifier.doi | 10.1515/bmc-2014-0017 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |