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dc.contributor.authorBriggs, Koan
dc.contributor.authorFischer, Christopher J.
dc.date.accessioned2015-12-16T17:07:26Z
dc.date.available2015-12-16T17:07:26Z
dc.date.issued2014-11
dc.identifier.citationBriggs, Koan, and Christopher J. Fischer. "All Motors Have to Decide Is What to Do with the DNA That Is given Them." Biomolecular Concepts 5.5 (2014). http://dx.doi.org/10.1515/bmc-2014-0017en_US
dc.identifier.urihttp://hdl.handle.net/1808/19201
dc.descriptionThis is the published version. Copyright 2014 De Gruyter.en_US
dc.description.abstractDNA translocases are a diverse group of molecular motors responsible for a wide variety of cellular functions. The goal of this review is to identify common aspects in the mechanisms for how these enzymes couple the binding and hydrolysis of ATP to their movement along DNA. Not surprisingly, the shared structural components contained within the catalytic domains of several of these motors appear to give rise to common aspects of DNA translocation. Perhaps more interesting, however, are the differences between the families of translocases and the potential associated implications both for the functions of the members of these families and for the evolution of these families. However, as there are few translocases for which complete characterizations of the mechanisms of DNA binding, DNA translocation, and DNA-stimulated ATPase have been completed, it is difficult to form many inferences. We therefore hope that this review motivates the necessary further experimentation required for broader comparisons and conclusions.en_US
dc.publisherDe Gruyteren_US
dc.subjectATPaseen_US
dc.subjectMolecular motoren_US
dc.subjectTranslocaseen_US
dc.titleAll motors have to decide is what to do with the DNA that is given themen_US
dc.typeArticle
kusw.kuauthorFischer, Christopher J.
kusw.kudepartmentPhysics and Astronomyen_US
dc.identifier.doi10.1515/bmc-2014-0017
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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