Enhanced cavitation by using two consecutive ultrasound waves at different frequencies
Issue Date
2014-11-10Author
Yang, Xinmai
Jo, Janggun
Publisher
American Institute of Physics
Type
Article
Article Version
Scholarly/refereed, publisher version
Metadata
Show full item recordAbstract
Efficient and noninvasive generation of cavitation bubbles in soft tissue is a challenging task due to the lack of cavitation nuclei (i.e., pre-existing gas bubbles). In this study, we present a method to generate and enhance cavitation activity based on the utilization of two consecutive ultrasound waves at different frequencies. First, a high frequency (5 MHz) high intensity focused ultrasound (HIFU) wave was applied to a tissue-mimicking phantom to induce a rapid temperature rise in the ultrasound focal region. Immediately following the high frequency HIFU wave, a low frequency (1 MHz) HIFU wave was applied to the same focal region to induce acoustic cavitation. We found that cavitation activity was enhanced when the temperature in the tissue-mimicking phantom was first elevated by the high frequency HIFU wave. The enhancement was greater when a higher intensity of high frequency HIFU wave was applied. This result may be due to the temporary super-saturation of air in the initially air-saturated test samples and the reduction of surface tension at an elevated temperature.
Description
This is the published version. Copyright 2014 American Institute of Physics
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Citation
Yang, Xinmai, and Janggun Jo. "Enhanced Cavitation by Using Two Consecutive Ultrasound Waves at Different Frequencies." Appl. Phys. Lett. Applied Physics Letters 105.19 (2014): 193701. http://dx.doi.org/10.1063/1.4902118
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