dc.contributor.author | Du, Heng | |
dc.contributor.author | Yan, Shirley ShiDu | |
dc.date.accessioned | 2015-05-28T16:20:11Z | |
dc.date.available | 2015-05-28T16:20:11Z | |
dc.date.issued | 2010-05-10 | |
dc.identifier.citation | Du, Heng, and Shirley Shidu Yan. "Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore." Pharmaceuticals 3.6 (2010): 1936-948. http://dx.doi.org/10.3390/ph3061936. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/17871 | |
dc.description | This is the published version. Copyright 2010 MDPI. | en_US |
dc.description.abstract | Mitochondrial dysfunction occurs early in the progression of Alzheimer’s disease. Amyloid-β peptide has deleterious effects on mitochondrial function and contributes to energy failure, respiratory chain impairment, neuronal apoptosis, and generation of reactive oxygen species in Alzheimer’s disease. The mechanisms underlying amyloid-β induced mitochondrial stress remain unclear. Emerging evidence indicates that mitochondrial permeability transition pore is important for maintenance of mitochondrial and neuronal function in aging and neurodegenerative disease. Cyclophilin D (Cyp D) plays a central role in opening mitochondrial permeability transition pores, ultimately leading to cell death. Interaction of amyloid-β with cyclophilin D triggers or enhances the formation of mitochondrial permeability transition pores, consequently exacerbating mitochondrial and neuronal dysfunction, as shown by decreased mitochondrial membrane potential, impaired mitochondrial respiration function, and increased oxidative stress and cytochrome c release. Blockade of cyclophilin D by genetic abrogation or pharmacologic inhibition protects mitochondria and neurons from amyloid-β induced toxicity, suggesting that cyclophilin D dependent mitochondrial transition pores are a therapeutic target for Alzheimer’s disease. | en_US |
dc.publisher | MDPI | en_US |
dc.title | Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore | en_US |
dc.type | Article | |
kusw.kuauthor | Yan, Shirley ShiDu | |
kusw.kudepartment | Pharmacology & Toxicology | en_US |
kusw.oanotes | Per SHERPA/RoMEO, 5/28/15: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing)
Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing)
Publisher's Version/PDF: green tick author can archive publisher's version/PDF
General Conditions: Publisher's version/PDF may be used
Published source must be acknowledged
Creative Commons Attribution License
Authors are encouraged to submit their published articles to institutional repositories | en_US |
dc.identifier.doi | 10.3390/ph3061936 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess | |