Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene
dc.contributor.author | Casimiro, Danilo R. | |
dc.contributor.author | Tang, Aimin | |
dc.contributor.author | Chen, Ling | |
dc.contributor.author | Fu, Tong-Ming | |
dc.contributor.author | Evans, Robert K. | |
dc.contributor.author | Davies, Mary-Ellen | |
dc.contributor.author | Freed, Daniel C. | |
dc.contributor.author | Hurni, William | |
dc.contributor.author | Aste-Amezaga, Jose M. | |
dc.contributor.author | Guan, Liming | |
dc.contributor.author | Long, Romnie | |
dc.contributor.author | Huang, Lingyi | |
dc.contributor.author | Harris, Virginia | |
dc.contributor.author | Nawrocki, Denise K. | |
dc.contributor.author | Mach, Henryk | |
dc.contributor.author | Troutman, Robert D. | |
dc.contributor.author | Isopi, Lynne | |
dc.contributor.author | Murthy, Krishna K. | |
dc.contributor.author | Rice, Karen | |
dc.contributor.author | Wilson, Keith A. | |
dc.contributor.author | Volkin, David B. | |
dc.contributor.author | Emini, Emilio A. | |
dc.contributor.author | Shiver, John W. | |
dc.date.accessioned | 2015-05-27T19:10:43Z | |
dc.date.available | 2015-05-27T19:10:43Z | |
dc.date.issued | 2003-07 | |
dc.identifier.citation | Casimiro, D. R., A. Tang, L. Chen, T.-M. Fu, R. K. Evans, M.-E. Davies, D. C. Freed, W. Hurni, J. M. Aste-Amezaga, L. Guan, R. Long, L. Huang, V. Harris, D. K. Nawrocki, H. Mach, R. D. Troutman, L. A. Isopi, K. K. Murthy, K. Rice, K. A. Wilson, D. B. Volkin, E. A. Emini, and J. W. Shiver. "Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 Gag Gene." Journal of Virology 77.13 (2003): 7663-668. http://dx.doi.org/10.1128/JVI.77.13.7663-7668.2003. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/17849 | |
dc.description | This is the published version. Copyright 2003 American Society for Microbiology. | en_US |
dc.description.abstract | The cellular immunogenicity of formulated plasmid DNA and replication-defective human adenovirus serotype 5 (Ad5) vaccine vectors expressing a codon-optimized human immunodeficiency virus type 1 gag gene was examined in baboons. The Ad5 vaccine was capable of inducing consistently strong, long-lived CD8+-biased T-cell responses and in vitro cytotoxic activities. The DNA vaccine-elicited immune responses were weaker than those elicited by the Ad5 vaccine and highly variable; formulation with chemical adjuvants led to moderate increases in the levels of Gag-specific T cells. Increasing the DNA-primed responses with booster doses of either Ad5 or modified vaccinia virus Ankara vaccines suggests a difference in the relative levels of cytotoxic and helper responses. The implications of these results are discussed. | en_US |
dc.publisher | American Society for Microbiology | en_US |
dc.title | Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene | en_US |
dc.type | Article | |
kusw.kuauthor | Volkin, David B. | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.1128/JVI.77.13.7663-7668.2003 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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