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Hyperglycemia as a Risk Factor of Ischemic Stroke

dc.contributor.authorZhang, Ziyan
dc.contributor.authorYan, Jingqi
dc.contributor.authorShi, Honglian
dc.date.accessioned2014-11-14T20:34:42Z
dc.date.available2014-11-14T20:34:42Z
dc.date.issued2013-06-29
dc.identifier.citationZiyan Zhang, Jingqi Yan, Honglian Shi. "Hyperglycemia as a Risk Factor of Ischemic Stroke." J Drug Metab Toxicol. Author manuscript; available in PMC 2014 October 15. Published in final edited form as: J Drug Metab Toxicol. 2013 June 29; 4(4): 153. Published online 2013 June 29. http://dx.doi.org/10.4172/2157-7609.1000153
dc.identifier.urihttp://hdl.handle.net/1808/15761
dc.description.abstractDiabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke.
dc.description.sponsorshipThis research was supported in part by a grant from the National Institutes of Health (R01NS058807) and a Kansas University Center for Research startup fund.
dc.publisherOMICS
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDiabetes
dc.subjectStroke
dc.subjectHyperglycemia
dc.subjectBBB
dc.subjectNeuroprotection
dc.titleHyperglycemia as a Risk Factor of Ischemic Stroke
dc.typeArticle
kusw.kuauthorZhang, Ziyan
kusw.kuauthorYan, Jingqi
kusw.kuauthorHonglian, Shi
kusw.kudepartmentDepartment of Pharmacology and Toxicology
kusw.oastatusfullparticipation
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Except where otherwise noted, this item's license is described as: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.