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dc.contributor.authorLanfranca, Mirna Perusina
dc.contributor.authorMostafa, Heba H.
dc.contributor.authorDavido, David J.
dc.date.accessioned2014-08-08T15:35:43Z
dc.date.available2014-08-08T15:35:43Z
dc.date.issued2014-05-20
dc.identifier.citationLanfranca, Mirna Perusina, Mostafa Heba H., Davido, David J. "HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity." MDPI. May 20, 2014.
dc.identifier.urihttp://hdl.handle.net/1808/14901
dc.descriptionThis is an Open Access article distributed under the terms of the Open Access Policy.
dc.description.abstractThe herpes simplex virus type 1 (HSV-1) encoded E3 ubiquitin ligase, infected cell protein 0 (ICP0), is required for efficient lytic viral replication and regulates the switch between the lytic and latent states of HSV-1. As an E3 ubiquitin ligase, ICP0 directs the proteasomal degradation of several cellular targets, allowing the virus to counteract different cellular intrinsic and innate immune responses. In this review, we will focus on how ICP0’s E3 ubiquitin ligase activity inactivates the host intrinsic defenses, such as nuclear domain 10 (ND10), SUMO, and the DNA damage response to HSV-1 infection. In addition, we will examine ICP0’s capacity to impair the activation of interferon (innate) regulatory mediators that include IFI16 (IFN γ-inducible protein 16), MyD88 (myeloid differentiation factor 88), and Mal (MyD88 adaptor-like protein). We will also consider how ICP0 allows HSV-1 to evade activation of the NF-κB (nuclear factor kappa B) inflammatory signaling pathway. Finally, ICP0’s paradoxical relationship with USP7 (ubiquitin specific protease 7) and its roles in intrinsic and innate immune responses to HSV-1 infection will be discussed.
dc.publisherMDPI
dc.subjectHerpes simplex virus
dc.subjectHSV
dc.subjectE3 ubiquitin ligase
dc.subjectInfected cell protein 0
dc.subjectICP0
dc.subjectIntrinsic immunity
dc.subjectInnate immunity
dc.titleHSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity
dc.typeArticle
kusw.kuauthorLanfranca, Mirna Perusina
kusw.kuauthorMostafa, Heba H.
kusw.kudepartmentMolecular Biosciences
kusw.oastatusfullparticipation
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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