KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Dissertations and Theses
    • Theses
    • View Item
    •   KU ScholarWorks
    • Dissertations and Theses
    • Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The Etiology of Thumb Carpometacarpal Osteoarthritis: Early Indications from In Vivo Joint Contact Mechanics

    Thumbnail
    View/Open
    Zheng_ku_0099M_13248_DATA_1.pdf (3.544Mb)
    Issue Date
    2014-05-31
    Author
    Zheng, Qi
    Publisher
    University of Kansas
    Format
    104 pages
    Type
    Thesis
    Degree Level
    M.S.
    Discipline
    Bioengineering
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
    Metadata
    Show full item record
    Abstract
    The thumb carpometacarpal (CMC) joint is frequently affected by osteoarthritis (OA). The prevalence of thumb CMC OA greatly increases with age and has disproportional predominance in postmenopausal women. However, so far the etiology of thumb CMC OA remains unclear, and no conclusion has been achieved regarding the selection of the optimal surgical procedure. Joint contact mechanics can be an important aspect in understanding the mechanism of thumb CMC OA development. The contact pressure distribution on the articular surface directly affects the cartilage condition. This study quantitatively compared the in vivo thumb CMC joint contact mechanics between 4 males and 4 females using finite element modeling (FEM), and also evaluated the accuracy of a time-efficient surface-based contact modeling (SCM) procedure for possible clinical application. Although a sufficient statistical power cannot be achieved with the small number of subjects, the contact patterns were substantially different between male and female groups. Contact area, force and peak contact pressure showed a trend of increase in the older female subjects. Compared with FEM, the contact parameter values from SCM may be somewhat less accurate, but SCM produced contact distribution patterns similar to FEM. In addition, SCM was able to distinguish the different contact patterns between normal and osteoarthritic thumb CMC joints with much less data processing. Therefore, SCM has clear potential for future clinical diagnosis and the evaluation of treatment efficacy for thumb CMC OA.
    URI
    http://hdl.handle.net/1808/14594
    Collections
    • Engineering Dissertations and Theses [1055]
    • Theses [3772]

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    Login

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps