KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Dissertations and Theses
    • Dissertations
    • View Item
    •   KU ScholarWorks
    • Dissertations and Theses
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Insulin Resistance, Depression, and the Progression to Type-2 Diabetes in Youth

    Thumbnail
    View/Open
    Platt_ku_0099D_13346_DATA_1.pdf (1.005Mb)
    Tables and Figures (82.56Kb)
    Issue Date
    2014-05-31
    Author
    Platt, Adrienne Milligan
    Publisher
    University of Kansas
    Format
    96 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Nursing
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
    Metadata
    Show full item record
    Abstract
    ABSTRACT Childhood obesity has become epidemic in the United States. Coinciding with this rapid increase in obesity is the development of type-2 diabetes in youth. Little is known about the progression of insulin resistance to type-2 diabetes or association of depressive symptoms and impaired glucose metabolism in at-risk obese youth. A retrospective chart review and a secondary data analysis was done using a descriptive correlational design exploring the incidence of insulin resistance, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, and progression to type-2 diabetes in a cohort of 78 high-risk obese youth age 11 to 17 years presenting to a pediatric endocrinology clinic from 2007 to 2009. Association between self-reported depressive symptom scores using the Center for Epidemiological Studies Depression Scale for Children (CES-DC) and measures above were also explored. Of the 78 participants enrolled in the original study, 44 (56.4%) underwent oral glucose tolerance testing, and 4 (9.1%) were diagnosed with impaired glucose tolerance. None had a confirmed diagnosis of type-2 diabetes over the 6 year study period. Two hour oral glucose tolerance results significantly correlated with the initial HbA1c (r=.470, p=.007), the sum of insulin levels (r=.518, p=.001), and HOMA-IR (r=.429, p=.007). The insulin total correlated with HOMA-IR (r=.553, p=.001). The incidence of self-reported depressive symptoms was high in 35 (49 %) participants (n=71). None of the measures of impaired glucose metabolism correlated with depression scores. These results indicate that even with a small sample of obese youth, 78 % met criteria for insulin resistance. The HbA1c correlated with 2-hour glucose tolerance test results. Glucose tolerance testing is used clinically for confirmatory diagnosis of impaired glucose tolerance and type-2 diabetes which support the use of HbA1c for screening youth. Despite lack of association between depressive symptoms and impaired glucose metabolism, 49% reported symptoms of depression with 11% moderate or severe. It would be prudent to screen all obese youth for depressive symptoms as this may impact their ability to implement lifestyle changes. Future research is needed with a larger prospective sample of high-risk obese youth to identify those more likely to develop type-2 diabetes and benefit from lifestyle interventions.
    URI
    http://hdl.handle.net/1808/14548
    Collections
    • Dissertations [4474]
    • KU Med Center Dissertations and Theses [464]

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps