Impact of Intercurrent Respiratory Infections on Lung Health in Infants Born <29 Weeks with BPD
Issue Date
2013-05-31Author
Taylor, Jane B.
Publisher
University of Kansas
Format
25 pages
Type
Thesis
Degree Level
M.S.
Discipline
Clinical Research
Rights
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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Abstract: Objective: To assess the impact of intercurrent respiratory infections on infants born <29 weeks gestation with bronchopulmonary dysplasia (BPD). Study Design: A retrospective cohort study was conducted on 111 infants born <29 weeks gestation with BPD in one academic center from 2008-2010. Results: Backward stepwise logistic regression showed viral infections significantly increased oxygen use with an OR of 15.5 [CI 3.4, 71.3]. Stratified bivariate Cochran-Mantel-Hansel chi-square analysis showed both viral and bacterial infections affected oxygen use (9% vs. 47%, p<0.0002 and 8% vs. 24%, p =0.02) with viral infections maintaining significance in the no/mild and severe BPD groups (2% vs. 40% p=0.02 and 26% vs. 83% p=0.02). Both viral and bacterial infections were associated with increased steroid use (11% to 29%, P=0.01 and 9% to 22%, p=0.03) but only viral infections were associated with an increased diuretic use in the combined BPD groups and no/mild BPD group (32% to 57%, P=0.02 and 10% to 50%, p=0.03). The Cochran-Armitage trend test showed that an increasing number of viral infections is associated with increased oxygen use (OR [95% CI] = 6.4 [2.3-17.4]), diuretic use (OR [95% CI] = 2.4 [1.1 - 5.2], p=0.02) and inhaled steroid use (OR [95% CI] = 2.2[1.003 - 5.2], p=0.049). Conclusions: Viral infections caused more long term pulmonary morbidity/mortality than bacterial infections on premature lung health over the first year of life.
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