HLA Genes in the Chuvashian Population from European Russia: Admixture of Central European and Mediterranean Populations
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Issue Date
2003-06-01Author
Arnaiz-Villena, Antonio
Martinez-Laso, Jorge
Moscoso, Juan
Livshits, Gregory
Zamora, Jorge
Gomez-Casado, Eduardo
Silvera-Redondo, Carlos
Melvin, Kristin L.
Crawford, Michael H.
Publisher
Wayne State University Press
Type
Article
Article Version
Scholarly/refereed, publisher version
Published Version
http://digitalcommons.wayne.edu/humbiol/vol75/iss3/6Metadata
Show full item recordAbstract
HLA alleles have been determined for the first time in individuals from the Chuvashian population by DNA typing and sequencing. HLA-A, -B, -DR, and -DQ allele frequencies and extended haplotypes have also been determined, and the results compared to those for Central Europeans, Siberians and other Asians, Caucasians, Middle Easterners, and Mediterranean peoples. Genetic distances, neighbor-joining dendrograms, and correspondence analysis have been performed. Present-day Chuvash speak an Altaic- Turkic language and are genetically related to Caucasians (Georgians), Mediterraneans, and Middle Easterners, and not only to Central or Northern Europeans; Chuvash contain little indications of Central Asian-Altaic gene flow. Thus, present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people.
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This is the publisher's version, also available electronically from http://digitalcommons.wayne.edu/humbiol/vol75/iss3/6/.
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Citation
Arnaiz-Villena, Antonio; Martinez-Laso, Jorge; Moscoso, Juan; Livshits, Gregory; Zamora, Jorge; Gomez-Casado, Eduardo; Silvera-Redondo, Carlos; Melvin, Kristin; and Crawford, Michael H. (2003) "HLA Genes in the Chuvashian Population from European Russia: Admixture of Central European and Mediterranean Populations," Human Biology: Vol. 75: Iss. 3, Article 6. http://digitalcommons.wayne.edu/humbiol/vol75/iss3/6
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