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dc.contributor.authorFenster, Erik
dc.contributor.authorHill, David
dc.contributor.authorReiser, Oliver
dc.contributor.authorAubé, Jeffrey
dc.date.accessioned2014-04-17T19:34:23Z
dc.date.available2014-04-17T19:34:23Z
dc.date.issued2012-10-19
dc.identifier.citationFenster, Erik, David Hill, Oliver Reiser, and Jeffrey Aube. 2012. “Automated Three-Component Synthesis of a Library of ?-Lactams.” Beilstein Journal of Organic Chemistry 8 : 1804–13. http://dx.doi.org/10.3762/bjoc.8.206
dc.identifier.urihttp://hdl.handle.net/1808/13540
dc.description.abstractA three-component method for the synthesis of γ-lactams from commercially available maleimides, aldehydes, and amines was adapted to parallel library synthesis. Improvements to the chemistry over previous efforts include the optimization of the method to a one-pot process, the management of by-products and excess reagents, the development of an automated parallel sequence, and the adaption of the method to permit the preparation of enantiomerically enriched products. These efforts culminated in the preparation of a library of 169 γ-lactams.
dc.description.sponsorshipThe authors are grateful to Ben Neuenswander for carrying out the purification of the libraries and to the National Institutes of General Medical Sciences for financial support through the University of Kansas Chemical Methodologies and Library Development center (P50 GM69663).
dc.publisherBeilstein-Institut
dc.rightsThis is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectΓ-lactam
dc.subjectMaleimide
dc.subjectOranocatalysis
dc.subjectParallel synthesis
dc.subjectReductive amination
dc.titleAutomated three-component synthesis of a library of γ-lactams
dc.typeArticle
kusw.kuauthorFenster, Erik
kusw.kuauthorHill, David
kusw.kuauthorReiser, Oliver
kusw.kuauthorAubé, Jeffrey
kusw.kudepartmentDepartment of Medicinal Chemistry
dc.identifier.doi10.3762/bjoc.8.206
dc.identifier.orcidhttps://orcid.org/0000-0003-1049-5767
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
Except where otherwise noted, this item's license is described as: This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)