Automated three-component synthesis of a library of γ-lactams
dc.contributor.author | Fenster, Erik | |
dc.contributor.author | Hill, David | |
dc.contributor.author | Reiser, Oliver | |
dc.contributor.author | Aubé, Jeffrey | |
dc.date.accessioned | 2014-04-17T19:34:23Z | |
dc.date.available | 2014-04-17T19:34:23Z | |
dc.date.issued | 2012-10-19 | |
dc.identifier.citation | Fenster, Erik, David Hill, Oliver Reiser, and Jeffrey Aube. 2012. “Automated Three-Component Synthesis of a Library of ?-Lactams.” Beilstein Journal of Organic Chemistry 8 : 1804–13. http://dx.doi.org/10.3762/bjoc.8.206 | |
dc.identifier.uri | http://hdl.handle.net/1808/13540 | |
dc.description.abstract | A three-component method for the synthesis of γ-lactams from commercially available maleimides, aldehydes, and amines was adapted to parallel library synthesis. Improvements to the chemistry over previous efforts include the optimization of the method to a one-pot process, the management of by-products and excess reagents, the development of an automated parallel sequence, and the adaption of the method to permit the preparation of enantiomerically enriched products. These efforts culminated in the preparation of a library of 169 γ-lactams. | |
dc.description.sponsorship | The authors are grateful to Ben Neuenswander for carrying out the purification of the libraries and to the National Institutes of General Medical Sciences for financial support through the University of Kansas Chemical Methodologies and Library Development center (P50 GM69663). | |
dc.publisher | Beilstein-Institut | |
dc.rights | This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc) | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | |
dc.subject | Γ-lactam | |
dc.subject | Maleimide | |
dc.subject | Oranocatalysis | |
dc.subject | Parallel synthesis | |
dc.subject | Reductive amination | |
dc.title | Automated three-component synthesis of a library of γ-lactams | |
dc.type | Article | |
kusw.kuauthor | Fenster, Erik | |
kusw.kuauthor | Hill, David | |
kusw.kuauthor | Reiser, Oliver | |
kusw.kuauthor | Aubé, Jeffrey | |
kusw.kudepartment | Department of Medicinal Chemistry | |
dc.identifier.doi | 10.3762/bjoc.8.206 | |
dc.identifier.orcid | https://orcid.org/0000-0003-1049-5767 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)