Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability
dc.contributor.author | Wang, Xinkun | |
dc.contributor.author | Michaelis, Mary Lou | |
dc.contributor.author | Michaelis, Elias K. | |
dc.date.accessioned | 2014-04-15T20:00:31Z | |
dc.date.available | 2014-04-15T20:00:31Z | |
dc.date.issued | 2010-10-21 | |
dc.identifier.citation | Wang, Xinkun, Mary L. Michaelis, and Elias K. Michaelis. 2010. “Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability.” Curr Genomics. 11(8): 618–633. http://dx. doi.org/10.2174/138920210793360943 | |
dc.identifier.uri | http://hdl.handle.net/1808/13516 | |
dc.description.abstract | Pivotal brain functions, such as neurotransmission, cognition, and memory, decline with advancing age and, especially, in neurodegenerative conditions associated with aging, such as Alzheimer’s disease (AD). Yet, deterioration in structure and function of the nervous system during aging or in AD is not uniform throughout the brain. Selective neuronal vulnerability (SNV) is a general but sometimes overlooked characteristic of brain aging and AD. There is little known at the molecular level to account for the phenomenon of SNV. Functional genomic analyses, through unbiased whole genome expression studies, could lead to new insights into a complex process such as SNV. Genomic data generated using both human brain tissue and brains from animal models of aging and AD were analyzed in this review. Convergent trends that have emerged from these data sets were considered in identifying possible molecular and cellular pathways involved in SNV. It appears that during normal brain aging and in AD, neurons vulnerable to injury or cell death are characterized by significant decreases in the expression of genes related to mitochondrial metabolism and energy production. In AD, vulnerable neurons also exhibit down-regulation of genes related to synaptic neurotransmission and vesicular transport, cytoskeletal structure and function, and neurotrophic factor activity. A prominent category of genes that are up-regulated in AD are those related to inflammatory response and some components of calcium signaling. These genomic differences between sensitive and resistant neurons can now be used to explore the molecular underpinnings of previously suggested mechanisms of cell injury in aging and AD. | |
dc.description.sponsorship | The work was supported by grants from the National Institute on Aging (NIA), AG12993 and AG025350, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), HD02528, the National Center for Research Resources (NCRR), RR-P20 17708, the Kansas Technology Enterprise Corporation, and the Miller-Hedwig-Wilbur Fund. | |
dc.publisher | Bentham Science | |
dc.rights | This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. A full online version this article can be found at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078686/ | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.5/ | |
dc.subject | Selective neuronal vulnerability | |
dc.subject | Aging | |
dc.subject | Alzheimer's disease | |
dc.subject | Functional genomics | |
dc.subject | Neuroinflammation | |
dc.subject | Energy metabolism | |
dc.subject | Synaptic neurotransmission | |
dc.title | Functional Genomics of Brain Aging and Alzheimer’s Disease: Focus on Selective Neuronal Vulnerability | |
dc.type | Article | |
kusw.kuauthor | Wang, Xinkun | |
kusw.kuauthor | Michaelis, Mary L. | |
kusw.kuauthor | Michaelis, Elias K. | |
kusw.kudepartment | Higuchi Bioscences | |
kusw.kudepartment | Department of Pharmacology and Toxicology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.2174/138920210793360943 | |
dc.identifier.orcid | https://orcid.org/0000-0003-1377-0509 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. A full online version this article can be found at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078686/