Evolution of Linear Mitochondrial Genomes in Medusozoan Cnidarians
dc.contributor.author | Kayal, Ehsan | |
dc.contributor.author | Bentlage, Bastian | |
dc.contributor.author | Collins, Allen G. | |
dc.contributor.author | Kayal, Mohsen | |
dc.contributor.author | Pirro, Stacy | |
dc.contributor.author | Lavrov, Dennis V. | |
dc.date.accessioned | 2014-04-15T13:42:59Z | |
dc.date.available | 2014-04-15T13:42:59Z | |
dc.date.issued | 2011-11-22 | |
dc.identifier.citation | Kayal, Ehsan, Bastian Bentlage, Allen G Collins, Mohsen Kayal, Stacy Pirro, and Dennis V Lavrov. 2012. “Evolution of Linear Mitochondrial Genomes in Medusozoan Cnidarians.” Genome Biology and Evolution 4 (1): 1–12. http://dx.doi.org/10.1093/gbe/evr123 | |
dc.identifier.uri | http://hdl.handle.net/1808/13484 | |
dc.description.abstract | In nearly all animals, mitochondrial DNA (mtDNA) consists of a single circular molecule that encodes several subunits of the protein complexes involved in oxidative phosphorylation as well as part of the machinery for their expression. By contrast, mtDNA in species belonging to Medusozoa (one of the two major lineages in the phylum Cnidaria) comprises one to several linear molecules. Many questions remain on the ubiquity of linear mtDNA in medusozoans and the mechanisms responsible for its evolution, replication, and transcription. To address some of these questions, we determined the sequences of nearly complete linear mtDNA from 24 species representing all four medusozoan classes: Cubozoa, Hydrozoa, Scyphozoa, and Staurozoa. All newly determined medusozoan mitochondrial genomes harbor the 17 genes typical for cnidarians and map as linear molecules with a high degree of gene order conservation relative to the anthozoans. In addition, two open reading frames (ORFs), polB and ORF314, are identified in cubozoan, schyphozoan, staurozoan, and trachyline hydrozoan mtDNA. polB belongs to the B-type DNA polymerase gene family, while the product of ORF314 may act as a terminal protein that binds telomeres. We posit that these two ORFs are remnants of a linear plasmid that invaded the mitochondrial genomes of the last common ancestor of Medusozoa and are responsible for its linearity. Hydroidolinan hydrozoans have lost the two ORFs and instead have duplicated cox1 at each end of their mitochondrial chromosome(s). Fragmentation of mtDNA occurred independently in Cubozoa and Hydridae (Hydrozoa, Hydroidolina). Our broad sampling allows us to reconstruct the evolutionary history of linear mtDNA in medusozoans. | |
dc.description.sponsorship | We would like to thank Dr Michael Dawson and Dr Alexander Ereskovsky for their contributions to the sampling effort of Scyphozoa, Dr Janet Voight for providing us with DNA from the staurozoan L. janetae, and Dr Annette F. Govindarajan for providing us with the hydrozoxan O. longissima. We also thank Dr Casey Dunn and the Cnidarian Tree of Life project (DEB-0531779 to Paulyn Cartwright and A.G.C.) for granting access to EST data from the scyphozoan C. capillata and H. “sanjuanensis.” We are very grateful to Dr Peter Schuchert for the identification of our hydrozoan samples. B.B. wishes to acknowledge funding through the USNational Science Foundation Doctoral Dissertation Grant DEB 0910237. E.K. wishes to acknowledge the funding through the Smithsonian Predoctoral Fellow grant. This work was supported by a grant from the National Science Foundation to D.V.L. (DEB-0829783) and by the funding from the Iowa State University. | |
dc.publisher | Oxford University Press | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is properly cited. | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | |
dc.subject | linear mtDNA | |
dc.subject | medusozoa | |
dc.subject | cnidaria | |
dc.subject | ORF314 | |
dc.subject | polB | |
dc.title | Evolution of Linear Mitochondrial Genomes in Medusozoan Cnidarians | |
dc.type | Article | |
kusw.kuauthor | Bentlage, Bastian | |
kusw.kudepartment | Department of Ecology and Evolutionary Biology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1093/gbe/evr123 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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