Turmeric inhibits parathyroid hormone-related protein (PTHrP) secretion from human rheumatoid synoviocytes

Frye, Jennifer B.; Timmermann, Barbara N.; Funk, Janet L.

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Issue Date

2012-06-12

Author

Frye, Jennifer B.

Timmermann, Barbara N.

Funk, Janet L.

Publisher

BioMed Central

Type

Article

Article Version

Scholarly/refereed, publisher version

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Abstract

Excessive production of parathyroid hormone-related protein (PTHrP) by tumor-like synoviocytes contributes to joint destruction in rheumatoid arthritis (RA). Having previously demonstrated that curcuminoid-only and essential oil-only fractions of turmeric prevent joint destruction in an animal model of RA, we hypothesized that synoviocyte PTHrP production could be one signaling pathway targeted by turmeric (Curcuma longa L.) in RA.

Citation

Frye, J, B Timmermann, and J Funk. 2012. “P01.55. Turmeric Inhibits Parathyroid Hormone-Related Protein (PTHrP) Secretion from Human Rheumatoid Synoviocytes.” BMC Complementary and Alternative Medicine 12 (Suppl 1): P55. http://dx.doi.org/10.1186/1472-6882-12-S1-P55.

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