Molecular evolution under increasing transposable element burden in Drosophila: A speed limit on the evolutionary arms race.
dc.contributor.author | Castillo, Dean M. | |
dc.contributor.author | Mell, Joshua Chang | |
dc.contributor.author | Box, Kimberly S. | |
dc.contributor.author | Blumenstiel, Justin P. | |
dc.date.accessioned | 2014-01-17T19:00:07Z | |
dc.date.available | 2014-01-17T19:00:07Z | |
dc.date.issued | 2011-01-01 | |
dc.identifier.citation | Castillo, Dean M, Joshua Chang Mell, Kimberly S Box, and Justin P Blumenstiel. 2011. “Molecular Evolution under Increasing Transposable Element Burden in Drosophila: A Speed Limit on the Evolutionary Arms Race.” BMC Evolutionary Biology 11: 258. http://dx.doi.org/10.1186/1471-2148-11-258 | |
dc.identifier.uri | http://hdl.handle.net/1808/12766 | |
dc.description.abstract | Genome architecture is profoundly influenced by transposable elements (TEs), and natural selection against their harmful effects is a critical factor limiting their spread. Genome defense by the piRNA silencing pathway also plays a crucial role in limiting TE proliferation. How these two forces jointly determine TE abundance is not well understood. To shed light on the nature of factors that predict TE success, we test three distinct hypotheses in the Drosophila genus. First, we determine whether TE abundance and relaxed genome-wide purifying selection on protein sequences are positively correlated. This serves to test the hypothesis that variation in TE abundance in the Drosophila genus can be explained by the strength of natural selection, relative to drift, acting in parallel against mildly deleterious non-synonymous mutations. Second, we test whether increasing TE abundance is correlated with an increased rate of amino-acid evolution in genes encoding the piRNA machinery, as might be predicted by an evolutionary arms race model. Third, we test whether increasing TE abundance is correlated with greater codon bias in genes of the piRNA machinery. This is predicted if increasing TE abundance selects for increased efficiency in the machinery of genome defense. | |
dc.language.iso | en | |
dc.publisher | BioMed Central | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.rights.uri | http://creativecommons.org/licenses/by/2.0 | |
dc.title | Molecular evolution under increasing transposable element burden in Drosophila: A speed limit on the evolutionary arms race. | |
dc.type | Article | |
kusw.kuauthor | Castillo, Dean M. | |
kusw.kuauthor | Box, Kimberly S. | |
kusw.kuauthor | Blumenstiel, Justin P. | |
kusw.kudepartment | Department of Ecology and Evolutionary Biology | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1186/1471-2148-11-258 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess |
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