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Genomic aggregation effects and Simpson's paradox

dc.contributor.authorBrimacombe, Michael
dc.date.accessioned2014-01-13T20:54:57Z
dc.date.available2014-01-13T20:54:57Z
dc.date.issued2014-01-08
dc.identifier.citationBrimacombe, M. (2014). Genomic aggregation effects and Simpson’s paradox. http://dx.doi.org/10.2147/OAMS.S52288
dc.identifier.urihttp://hdl.handle.net/1808/12722
dc.descriptionA grant from the One-University Open Access Fund at the University of Kansas was used to defray the author’s publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.
dc.description.abstractGenomic studies have become commonplace, with thousands of gene expressions typically collected on single or multiple platforms and analyzed. Unaccounted time-ordered or epigenetic aspects of genetic expression may lead to a version of Simpson's paradox, ie, time-aggregated overall effects that do not reflect within strata patterns. Without clear functional models to motivate clustering and fitting algorithms, these confounding related issues require consideration. Several basic examples motivate discussion and more appropriate models for analysis of expression data are reviewed.
dc.publisherDove Medical Press Ltd
dc.rightsThis work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/
dc.subjectSimpson's paradox
dc.subjectaggregation effects
dc.subjectmediation
dc.subjectgenomics
dc.titleGenomic aggregation effects and Simpson's paradox
dc.typeArticle
kusw.kuauthorBrimacombe, Michael
kusw.kudepartmentBiostatistics
kusw.oanotesThe processing fees for this article were funded by The One - University Open Access Fund.
kusw.oastatusfullparticipation
dc.identifier.doi10.2147/OAMS.S52288
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.
Except where otherwise noted, this item's license is described as: This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.