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Dissertations and Theses: Recent submissions
Now showing items 1461-1480 of 9900
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Improving Clinical Trials Through Enrichment and Historical Controls
(University of Kansas, 2020-05-31)Abstract In this dissertation, Bayesian adaptive design used to identify subgroup treatment effect is firstly explored. We investigate three Bayesian adaptive models for subgroup treatment effect identification: pairwise ... -
Roles of IFT-A paralogs, Thm1 and Thm2, in the pathogenesis of ciliopathies
(University of Kansas, 2020-05-31)Primary cilia are antenna-like sensory organelles that extend from the apical surface of most vertebrate cells. Mutation of ciliary genes results in ciliopathies, which commonly manifest renal and hepatic cystic diseases, ... -
RNA binding protein RBM3 modulates novel lncRNAs to increase colon cancer tumor progression
(University of Kansas, 2020-0-31)RNA binding proteins play a significant role in regulating gene expression, and dysregulation in their expression may skew cells to various pathophysiological conditions. In previous studies, the Anant laboratory has shown ... -
Methods for Improving Inference in Clinical Outcomes
(University of Kansas, 2020-05-31)Advances in technology have allowed for the collection of diverse data types along with evolution in computer algorithms. This dissertation focuses on the development and application of novel methodologies to model and ... -
Methodological Developments for the Analysis of Biological Samples in the Presence of Compositional Effects
(University of Kansas, 2020-05-31)Compositional data, in which a vector of observed variables are constrained by a sum total, imposes a unique correlation structure among its components. Considering the abundance of components in a biological sample is ... -
Unraveling Clusters of Influential and Sex-Specific Risk Factors in the Progression to Alzheimer's Disease
(University of Kansas, 2020-05-31)Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting cognition, daily functioning, and quality of life. Women are disproportionately affected by Alzheimer’s disease, with two-thirds of patients ... -
Insomnia and Type 2 Diabetes: Measurements, Impacts and Interventions
(University of Kansas, 2020-05-31)Insomnia and type 2 diabetes (T2D) are common chronic health conditions in modern life. In the general population, 1 out of 10 are diagnosed with T2D, and 2 out of 10 have complained of insomnia symptoms. Further, more ... -
The Benefits of Walking Training Program to Cardiovascular Health in Individuals with Chronic Spinal Cord Injury
(University of Kansas, 2020-05-31)Background: Spinal cord injury (SCI) is a serious medical condition that impacts sensorimotor function and quality of life. Following SCI, individuals are subjected to various secondary complications, including cardiovascular ... -
Cognitive Workload during Dual-tasking and its Relationship with Falls in Parkinson’s Disease
(University of Kansas, 2020-08-31)Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world. Individuals with PD are at high risk of falling due to degeneration of dopaminergic and cholinergic pathways in the basal ganglia. ... -
Ovulatory Dysfunction and Compromised Granulosa Cells: Where does Adar fit?
(University of Kansas, 2020-08-31)Mural granulosa cells (mGCs) undergo waves of proliferation throughout the reproductive lifespan, and facilitate a timely gene expression response to the surge of luteinizing hormone in order to achieve ovulation and corpus ... -
Improving Breastfeeding Education
(University of Kansas, 2020-05-31)Breastfeeding provides many health and psychological benefits to both mother and child. Many women initiate breastfeeding to obtain these benefits for themselves and their child. However, breastfeeding rates in the United ... -
The Association Between Immunization Information Systems and Immunizations in Children 19-35 Months of Age in the United States.
(University of Kansas, 2020-05-31)In 2017, only 70.4% of U.S. children ages 19-35 months were up-to-date (UTD) for their routine series of vaccines, a rate that consistently misses the national target of 80%. Recent evidence has demonstrated that those ... -
Disparities in Ovarian Cancer Survival at the only NCI-designated Cancer Center in Kansas
(University of Kansas, 2020-05-31)Ovarian cancer is the fifth most deadly cancer among women and the deadliest gynecologic cancer in the United States. Although it is a relatively rare form of cancer, its toll on morbidity and mortality is not equally ... -
Using a Social Determinants of Health Framework to Understand Clinical Trial Participation, Long-term Follow-up, and Outcomes Among Women Leaving Jail
(University of Kansas, 2020-05-31)Abstract Background: Participants from vulnerable populations in most modern clinical trials are underrepresented thereby impacting the generalizability of clinical trial results. This is particularly worrisome – where the ... -
The Changing Health and Social Circumstances of Women Leaving Jails: A Three-Year Study
(University of Kansas, 2020-05-31)Ninety-five percent of all inmates are eventually released back into communities. Women, in particular, face complex health and social challenges before incarceration that they must also face upon reentry. Unfortunately, ... -
H-closed extensions as para-uniform completions
(University of Kansas, 1971-05-31) -
In Bloom: Women and Horticulture in French Visual Culture, 1860s–1880s
(University of Kansas, 2020-05-31)Evocative of fresh scents and organic forms, the phrase “in bloom” denotes a stage of growth in a plant’s life cycle and a period of rapid development, expansion, and flourishing. Drawing on these associations, my dissertation ... -
Paleoecology of ostracoda from quanternary sediments of the Great Salt Lake Basin, Utah
(University of Kansas, 1974-12-31)Stratigraphic collections were made from two cores more than 200 m long taken in Quaternary sediments of the Great Salt Lake Basin, Utah, in order to trace temporal changes in the complexity of the lacustrine ostracode ... -
Acting Like a Pianist : Music for the Theatrical Pianist
(University of Kansas, 2008-05-31)In the twentieth-century, there has been an explosion in explicitly theatrical pieces for solo piano. In most of these works, the pianist's ability to vocalize while at the same time playing the instrument has been the ... -
Origin of four Upper Pennsylvanian (Missourian) cyclothems in the subsurface of western Kansas : application to search for accumulation of petroleum
(1985-05-31)Thin, widespread, carbonate-dominated cyclothems of the Lansing, and Kansas City groups were deposited across Kansas during the Missourian on a gently tilted shelf bordering the rapidly subsiding Anadarko basin. The possible ...