| dc.contributor.advisor | Hanson, Paul R. | |
| dc.contributor.author | Knudtson, Christopher Anton | |
| dc.date.accessioned | 2013-01-20T18:24:10Z | |
| dc.date.available | 2013-01-20T18:24:10Z | |
| dc.date.issued | 2011-05-31 | |
| dc.date.submitted | 2011 | |
| dc.identifier.other | http://dissertations.umi.com/ku:11525 | |
| dc.identifier.uri | http://hdl.handle.net/1808/10706 | |
| dc.description.abstract | The utilization of Baylis-Hillman and oxa-Michael methodologies for the synthesis of sultam (cyclic sulfonamides) libraries from chiral non-racemic amino alcohols and epoxides is reported. These strategies employ a divergent synthetic approach utilizing a central vinyl sulfonamide linchpin and a variety of functional group pairing reactions to generate skeletally diverse sultam scaffolds with a variety of functionalizable handles. A variety of 5, 6, 7, and 8-member sultams are accessible through these methods with excellent diastereoselectivity, yields, and purities. In addition, the oxa-Michael protocol has been utilized in a one-pot protocol for the synthesis of alibrary of 4,4-dioxo-1,4,5-oxathiazepines. | |
| dc.format.extent | 91 pages | |
| dc.language.iso | en | |
| dc.publisher | University of Kansas | |
| dc.rights | This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author. | |
| dc.subject | Chemistry | |
| dc.title | Intramolecular oxa-Michael and Baylis Hillman Strategies towards Sultam Libraries | |
| dc.type | Thesis | |
| dc.contributor.cmtemember | Carlson, Robert G. | |
| dc.contributor.cmtemember | Givens, Richard S | |
| dc.thesis.degreeDiscipline | Chemistry | |
| dc.thesis.degreeLevel | M.S. | |
| kusw.oastatus | na | |
| kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
| kusw.bibid | 7643267 | |
| dc.rights.accessrights | openAccess | |
