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    An experimental method for evaluating the contribution of deleterious mutations to quantitative trait variation

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    Issue Date
    1999-06
    Author
    Kelly, John K.
    Publisher
    Cambridge University Press
    Format
    345239 bytes
    Type
    Article
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    Abstract
    Unconditionally deleterious mutations could be an important source of variation in quantitative traits. Deleterious mutations should be rare (segregating at low frequency in the population) and at least partially recessive. In this paper, I suggest that the contribution of rare, partially recessive alleles to quantitative trait variation can be assessed by comparing the relative magnitudes of two genetic variance components: the covariance of additive and homozygous dominance effects (Cad) and the additive genetic variance (Va). If genetic variation is due to rare recessives, then the ratio of Cad to Va should be equal to or greater than 1. In contrast, Cad/Va should be close to zero or even negative if variation is caused by alleles at intermediate frequencies. The ratio of Cad to Va can be estimated from phenotypic comparisons between inbred and outbred relatives, but such estimates are likely to be highly imprecise. Selection experiments provide an alternative estimator for Cad/Va, one with favourable statistical properties. When combined with other biometrical analyses, the ratio test can provide an incisive test of the deleterious mutation model.
    URI
    http://hdl.handle.net/1808/1042
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    • Ecology & Evolutionary Biology Scholarly Works [1497]
    Citation
    Kelly, John K. An experimental method for evaluating the contribution of deleterious mutations to quantitative trait variation. Genetical Research. June 1999. 73(3) 263-273.

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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