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In-plane Extended Nano-coulter Counter (XnCC) for the Label-free Electrical Detection of Biological Particles
Zhao, Zheng Vaidyanathan, Swarnagowri Bhanja, Payel Gamage, Sachindra Saha, Subhrajit McKinney, Collin Choi, Junseo Park, Sunggook Pahattuge, Thilanga Wijerathne, Harshani
Zhao, Zheng
Vaidyanathan, Swarnagowri
Bhanja, Payel
Gamage, Sachindra
Saha, Subhrajit
McKinney, Collin
Choi, Junseo
Park, Sunggook
Pahattuge, Thilanga
Wijerathne, Harshani
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Abstract
We report an in-plane extended nanopore Coulter counter (XnCC) chip fabricated in a thermoplastic via imprinting. The fabrication of the sensor utilized both photolithography and focused ion beam milling to make the microfluidic network and the in-plane pore sensor, respectively, in Si from which UV resin stamps were generated followed by thermal imprinting to produce the final device in the appropriate plastic (cyclic olefin polymer, COP). As an example of the utility of this in-plane extended nanopore sensor, we enumerated SARS-CoV-2 viral particles (VPs) affinity-selected from saliva and extracellular vesicles (EVs) affinity-selected from plasma samples secured from mouse models exposed to different ionizing radiation doses.
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This is the peer reviewed version of the following article: Z. Zhao, S. Vaidyanathan, P. Bhanja, S. Gamage, S. Saha, C. McKinney, J. Choi, S. Park, T. Pahattuge, H. Wijerathne, J. M. Jackson, M. L. Huppert, M. A. Witek, S. A. Soper, Electroanalysis 2022, 34, 1961., which has been published in final form at https://doi.org/10.1002/elan.202200091. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Date
2022-06-14
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Wiley
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Keywords
Coulter counter, Nanoparticles, COVID-19, Exosomes
Citation
Z. Zhao, S. Vaidyanathan, P. Bhanja, S. Gamage, S. Saha, C. McKinney, J. Choi, S. Park, T. Pahattuge, H. Wijerathne, J. M. Jackson, M. L. Huppert, M. A. Witek, S. A. Soper, Electroanalysis 2022, 34, 1961.