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A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis
Shao, Wei Paul, Arghya Abbasi, Sana Chahal, Parminder S. Mena, Jimmy A. Montes, Johnny Kamen, Amine Prakash, Satya
Shao, Wei
Paul, Arghya
Abbasi, Sana
Chahal, Parminder S.
Mena, Jimmy A.
Montes, Johnny
Kamen, Amine
Prakash, Satya
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Abstract
Systemic delivery of small interfering RNA (siRNA) is limited by its poor stability and limited cell-penetrating properties. To overcome these limitations, we designed an efficient siRNA delivery system using polyethyleneimine-coated virus-like particles derived from adeno-associated virus type 2 (PEI-AAV2-VLPs).
Description
Date
2012
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Publisher
Dove Medical Press
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Keywords
Adeno-associated virus type 2, Virus-like particles, Small interfering RNA delivery, Breast cancer therapy, Nanomedicine
Citation
Prakash, Satya, Ms Wei Shao, Arghya Paul, Sana Abbasi, Parminder Chahal, Jimmy A. Mena, Johnny Montes, and Amine Kamen. "A Novel Polyethyleneimine-coated Adeno-associated Virus-like Particle Formulation for Efficient SiRNA Delivery in Breast Cancer Therapy: Preparation and in Vitro Analysis." International Journal of Nanomedicine IJN (2012): 1575. http://dx.doi.org/10.2147/IJN.S26891