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Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release
Moise, Alexander R. Grant, Jason R. Vitalis, Timothy Z. Jefferies, Wilfred A.
Moise, Alexander R.
Grant, Jason R.
Vitalis, Timothy Z.
Jefferies, Wilfred A.
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Abstract
E3-6.7K is a small and hydrophobic membrane glycoprotein encoded by the E3 region of subgroup C adenovirus. Recently, E3-6.7K has been shown to be required for the downregulation of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors by the adenovirus E3/10.4K and E3/14.5K complex of proteins. We demonstrate here that E3-6.7K has additional protective roles, independent of other virus proteins. In transfected Jurkat T-cell lymphoma cells, E3-6.7K was found to maintain endoplasmic reticulum-Ca2+ homeostasis and inhibit the induction of apoptosis by thapsigargin. The presence of E3-6.7K also lead to a reduction in the TNF-induced release of arachidonic acid from transfected U937 human histiocytic lymphoma cells. In addition, E3-6.7K protected cells against apoptosis induced through Fas, TNF receptor, and TRAIL receptors. Therefore, E3-6.7K confers a wide range of protective effects against both Ca2+ flux-induced and death receptor-mediated apoptosis.
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This is the publisher's version, also available electronically from http://jvi.asm.org/content/76/4/1578
Date
2002-02
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American Society for Microbiology
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Moise, Alexander et al. (2002). Adenovirus E3-6.7K Maintains Calcium Homeostasis and Prevents Apoptosis and Arachidonic Acid Release. Journal of Virology 76(4):1578-1587. http://www.dx.doi.org/10.1128/JVI.76.4.1578-1587.2002